Early stage periarticular injection during total knee arthroplasty may provide a better postoperative pain relief than late-stage periarticular injection: a randomized-controlled trial

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
S TsukadaNaoyuki Hirasawa

Abstract

This study was performed to determine whether periarticular injection performed in the early stage of total knee arthroplasty (TKA) could provide a better postoperative pain relief than periarticular injection performed in the late stage of TKA. The hypothesis was based on the concept that analgesic intervention before the onset of noxious stimuli would be associated with less postoperative pain. A total of 105 participants were randomly assigned to receive superficial injection just prior to arthrotomy (early stage periarticular injection group) or superficial injection after implanting the prosthesis (late-stage periarticular injection group) in patients undergoing unilateral TKA with 1:1 treatment allocation. In both groups, deep injection was performed according to the same schedule (just prior to implanting prosthesis). The solution consisted of 300 mg of ropivacaine, 8 mg of morphine, 40 mg of methylprednisolone, 50 mg of ketoprofen, and 0.3 mg of epinephrine mixed with normal saline to a final volume of 60 mL. All surgeries were managed under general anesthesia without any regional blocks. Registry-specified primary outcome was postoperative pain score at rest measured at the recovery room using a 100-mm visual analog sc...Continue Reading

References

Dec 1, 1989·Controlled Clinical Trials·R JaeschkeG H Guyatt
Oct 6, 2000·Anesthesiology·I Kissin
Dec 6, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·P E BijurE J Gallagher
Feb 25, 2005·Anesthesia and Analgesia·Cliff K-S OngBrian J Jenkins
Feb 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Pascal-André VendittoliFrance Varin
May 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Constant A BuschRichard W McCalden
Nov 21, 2007·The Journal of Arthroplasty·Amar S Ranawat, Chitranjan S Ranawat
Jan 6, 2009·The Journal of Bone and Joint Surgery. American Volume·Daniel D GalatHenry D Clarke
Feb 14, 2009·Clinical Orthopaedics and Related Research·Aditya V MaheshwariChitranjan S Ranawat
Oct 5, 2012·The New England Journal of Medicine·Roderick J LittleHal Stern
Jan 19, 2017·The Journal of Bone and Joint Surgery. American Volume·Gwo-Chin Lee
Dec 6, 2017·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kenji KurosakaShinichi Yoshiya
Jun 26, 2018·Clinical Orthopaedics and Related Research·Naoyuki HirasawaSachiyuki Tsukada

❮ Previous
Next ❯

Software Mentioned

EZR
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.