Early-stage visual processing abnormalities in high-functioning autism spectrum disorder (ASD).

Translational Neuroscience
Joshua M BaruthEstate M Sokhadze

Abstract

It has been reported that individuals with autism spectrum disorder (ASD) have abnormal responses to the sensory environment. For these individuals sensory overload can impair functioning, raise physiological stress, and adversely affect social interaction. Early-stage (i.e. within 200ms of stimulus onset) auditory processing abnormalities have been widely examined in ASD using event-related potentials (ERP), while ERP studies investigating early-stage visual processing in ASD are less frequent. We wanted to test the hypothesis of early-stage visual processing abnormalities in ASD by investigating ERPs elicited in a visual oddball task using illusory figures. Our results indicate that individuals with ASD have abnormally large cortical responses to task irrelevant stimuli over both parieto-occipital and frontal regions-of-interest (ROI) during early stages of visual processing compared to the control group. Furthermore, ASD patients showed signs of an overall disruption in stimulus discrimination, and had a significantly higher rate of motor response errors.

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Citations

Feb 9, 2012·Applied Psychophysiology and Biofeedback·Estate M SokhadzeManuel F Casanova
Oct 1, 2014·Applied Psychophysiology and Biofeedback·Estate M SokhadzeManuel F Casanova
Jan 10, 2013·Cognitive, Affective & Behavioral Neuroscience·Alexander Dovgopoly, Eduardo Mercado
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Nov 7, 2014·Frontiers in Human Neuroscience·Manuel Fernando CasanovaLonnie Sears
Aug 1, 2016·Journal of Autism and Developmental Disorders·K KovarskiM Batty
Feb 18, 2017·Nature Reviews. Neurology·Meera E Modi, Mustafa Sahin
Jan 12, 2017·Behavioural Neurology·Rahul SinghBrandon P Lucke-Wold
Nov 17, 2017·Behavioral Sciences·Estate M SokhadzeManuel F Casanova
Jul 5, 2017·Journal of Psychopharmacology·Theresa VeltriPaul G Overton
Sep 11, 2020·Neuroscience and Biobehavioral Reviews·Eduardo MercadoChristopher Lopata

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