PMID: 9541205Apr 16, 1998Paper

Early stages of tooth morphogenesis in mouse analyzed by 3D reconstructions

European Journal of Oral Sciences
Hervé LesotJ V Ruch

Abstract

Computer-aided 3D reconstructions were used to investigate early odontogenesis in the ICR mouse, from the dental lamina to the cap stage. The diastemal region of the maxilla was not an empty zone: five transient epithelial rudiments (D1-D5) were found between ED 12.5-13.5. Two further rudiments (R1 and R2) were observed between D5 and the maxillary first molar primordium, whose bud emerged at ED 13.5. These rudiments might be related to vestiges of ancestral teeth. During this period, only an epithelial lamina was observed in front of the bud-shaped molar epithelium in the cheek region of the mandible. Apoptosis plays an important role in the reduction of antemolar rudiments in the maxilla and in the remodeling of the epithelium anterior to the M1 bud and cap in both jaws: two successive waves of apoptosis were detected in the mandible and in the maxilla. Computer-aided 3D reconstructions clearly demonstrated that morphologically different developmental stages coexist along the anteroposterior axis of M1 in both jaws.

Citations

Dec 20, 2002·Connective Tissue Research·R PeterkováH Lesot
Feb 8, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Renata PeterkovaMiroslav Peterka
Nov 19, 2010·European Journal of Oral Sciences·Jan StembírekIvan Míšek
Feb 6, 2014·Australian Dental Journal·R PeterkovaH Lesot
Apr 22, 2015·BMC Developmental Biology·Katerina LochovskaMaria Hovorakova
Jan 15, 2014·PloS One·Virginie Laugel-HaushalterAgnès Bloch-Zupan
Mar 26, 2008·Journal of Dental Research·G H YuanZ Chen
Feb 13, 2020·ELife·Luke HaydenSophie Pantalacci
Mar 7, 2002·European Journal of Oral Sciences·Yves CamHervé Lesot
Apr 5, 2018·Journal of Developmental Biology·Maisa SeppalaMartyn T Cobourne
Apr 4, 2021·Journal of Developmental Biology·Daisy Jihyung KoJulia C Boughner

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