Aug 1, 2015

Early statin use in ischemic stroke patients treated with recanalization therapy: retrospective observational study

BMC Neurology
Jihoon KangHee-Joon Bae


We aimed to determine whether early statin use following recanalization therapy improves the functional outcome of ischemic stroke. Using a prospective stroke registry database, we identified a consecutive 337 patients within 6 h of onset who had symptomatic stenosis or occlusion of major cerebral arteries and received recanalization therapy. Based on commencement of statin therapy, patients were categorized into administration on the first (D1, 13.4%), second (D2, 20.8%) and third day or later (D ≥ 3, 15.4%) after recanalization therapy, and no use (NU, 50.4%). The primary efficacy outcome was a 3-month modified Rankin Scale score of 0-1, and the secondary outcomes were neurologic improvement, neurologic deterioration and symptomatic hemorrhagic transformation during hospitalization. Earlier use of statin was associated with a better primary outcome in a dose-response relationship (P for trend = 0.01) independent of premorbid statin use, stroke history, atrial fibrillation, stroke subtype, calendar year, and methods of recanalization therapy. The odds of a better primary outcome increased in D1 compared to NU (adjusted odds ratio, 2.96; 95% confidence interval, 1.19-7.37). Earlier statin use was significantly associated with l...Continue Reading

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Mentioned in this Paper

Ischemic Cerebrovascular Accident
Neuro-Oncological Ventral Antigen 2
Electronic Health Records
Diagnostic Radiology Modality
Kruskal-Wallis Test
Blood Vessel
Dose-response Relationship

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