Early stem cell transplantation for chronic lymphocytic leukaemia: a chance for cure?

British Journal of Cancer
P DregerN Schmitz

Abstract

B-cell chronic lymphocytic leukaemia (CLL) cannot be cured by conventional therapy. To improve the prognosis of patients with CLL, we have designed a sequential treatment strategy that comprises intensive chemotherapy for mobilization of peripheral blood progenitor cells (PBPCs) and induction of minimal disease, followed by high-dose radiochemotherapy with stem cell reinfusion and post-transplant molecular monitoring by polymerase chain reaction (PCR) amplification of the complementary determining region III (CDRIII) gene. In a prospective study, we have evaluated this protocol in 18 patients with CLL, also including early stages of the disease. The median age was 49 (29-61) years; Binet stages were A, six; B, nine; and C, three. Adverse prognostic factors [high lymphocyte count and/or diffuse bone marrow (BM) infiltration] were present in 16 out of 18 patients. All patients showed a clone-specific molecular marker as demonstrated by PCR amplification of CDRIII rearrangements. For stem cell mobilization and reduction of tumour load, one to two cycles of Dexa-BEAM chemotherapy were administered, resulting in minimal disease (circulating lymphoma cells <1 x 10(9) l(-1); BM infiltration <20%; lymphomas <2 cm) in 16 out of 18 patie...Continue Reading

Citations

Jul 9, 2004·The Tohoku Journal of Experimental Medicine·Atsushi HoshinoTakeshi Sasaki
Jul 10, 1999·Current Opinion in Hematology·W G Wierda, T J Kipps
Jun 12, 2003·Current Opinion in Hematology·Vassiliki Rizouli, John G Gribben
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul MoretonPeter Hillmen
Jan 11, 2005·British Journal of Haematology·S Paneesha, D W Milligan
Feb 1, 2007·Current Hematologic Malignancy Reports·Rifca Le Dieu, John G Gribben
Jan 14, 2020·The Journal of Clinical Investigation·Chi LuoPere Puigserver
Oct 14, 2005·Expert Review of Anticancer Therapy·Edgardo S SantosHana Safah
Nov 5, 1999·Current Opinion in Hematology·A Krackhardt, J G Gribben

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