Early striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatment

Psychological Medicine
S E ChuaG M McAlonan

Abstract

We and others have reported that patients experiencing their first episode of psychosis already have significant structural brain abnormalities. Antipsychotics seem to reverse subcortical volume deficits after months of treatment. However, the early impact of medication on brain morphology is not known. Forty-eight individuals in their first episode of psychosis underwent magnetic resonance imaging (MRI) brain scanning. Twenty-six were antipsychotic naive and 22 were newly treated with antipsychotic medication for a median period of 3 weeks. In each group, 80% of subjects received a diagnosis of schizophrenia. The two groups were balanced for age, sex, handedness, ethnicity, height, years of education, paternal socio-economic status (SES) and Positive and Negative Syndrome Scale (PANSS) score. Group differences in whole-brain grey matter were compared voxel by voxel, using Brain Activation and Morphological Mapping (BAMM) software. We also conducted testing of group differences with region-of-interest (ROI) measurements of the caudate nucleus. Relative to the untreated group, those receiving antipsychotic medication for 3-4 weeks had significantly greater grey-matter volumes in the bilateral caudate and cingulate gyri, extendin...Continue Reading

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Citations

Nov 19, 2010·Schizophrenia Bulletin·Philip R SzeszkoDelbert G Robinson
Jul 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Siew E Chua, Grainne McAlonan
Oct 13, 2012·International Review of Psychiatry·Janardhanan C NarayanaswamyBangalore N Gangadhar
Dec 6, 2014·Frontiers in Behavioral Neuroscience·Chuanjun ZhuoChunshui Yu
Oct 27, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Henrik Nørbak-EmigBjørn H Ebdrup
Apr 6, 2018·Journal of Clinical Psychopharmacology·Ronald W Pies
Oct 3, 2013·European Archives of Psychiatry and Clinical Neuroscience·Berend MalchowThomas Wobrock
Feb 25, 2011·Journal of Clinical Psychopharmacology·Geartsje BoonstraRené S Kahn
Nov 9, 2015·European Archives of Psychiatry and Clinical Neuroscience·Kjetil N JørgensenIngrid Agartz

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