Early structural changes of aortic wall in sinoaortic-denervated rats

Clinical and Experimental Pharmacology & Physiology
Fu-Ming ShenDing-Feng Su

Abstract

1. The present work was designed to observe the early structural changes in the aortic wall in Sprague-Dawley rats 1, 2 and 4 weeks after sinoaortic denervation (SAD). 2. Rats were examined 1, 2 and 4 weeks after SAD. Blood pressure (BP) was recorded in the conscious state. The thoracic aortas were taken for investigations, including: light microscopy, electron microscopy, immunohistochemistry and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labelling (TUNEL). 3. Blood pressure variability (BPV) was significantly increased in the SAD groups 1, 2 and 4 after the operation when compared with the sham-operated ones. 4. Two weeks after SAD the percentage proportion of smooth muscle cell density (SMC%) was obviously increased. 5. Four weeks after SAD: the SMC%, percentage proportion of collagen density (CD%) and aortic wall thickness (WT) were obviously increased with vascular smooth muscle cells blebbing concomitantly. Endothelial cells showed degenerative changes and swelling with blebbing of the cell membrane and increased condensation of peripheral nuclear chromatin and cytoplasmic vacuolization. It was also found that the number of apoptotic endothelial cells was increased and expression of eNOS was reduce...Continue Reading

References

Jul 1, 1997·Journal of Vascular Research·N J BoerthT M Lincoln
Jan 11, 2001·Journal of Cardiovascular Pharmacology·C Y MiaoD F Su
Sep 13, 2001·Clinical and Experimental Pharmacology & Physiology·D F Su, C Y Miao
Jan 28, 2003·Journal of Cardiovascular Pharmacology·He-Hui XieDing-Feng Su
Jul 10, 2003·American Journal of Hypertension·Chao-Yu MiaoDing-Feng Su
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Xia TaoDing-Feng Su
Nov 5, 2003·Journal of Hypertension·Chuan ZhangDing-Feng Su
Apr 9, 2004·Journal of Cardiovascular Pharmacology·Chuan ZhangDing-Feng Su
May 24, 2005·Atherosclerosis·Guo-Jun CaiDing-Feng Su

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Citations

May 11, 2013·Cardiovascular Diabetology·Zhong-Wei YangFu-Ming Shen
Nov 6, 2007·Biological & Pharmaceutical Bulletin·Matheus Lavorenti Rocha, Lusiane Maria Bendhack
Nov 16, 2010·Canadian Journal of Physiology and Pharmacology·Yong-Sheng YuDing-Feng Su
Sep 9, 2008·Journal of Pharmacological Sciences·Jian-Guang YuDing-Feng Su
May 14, 2014·Journal of the American Heart Association·Changning HaoJun-Li Duan
Apr 27, 2011·Molecular and Cellular Biochemistry·Xiao-Song GuYong-Wen Qin
Sep 5, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Nathalie NasrVincent Larrue

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