Early surfactant in spontaneously breathing with nCPAP in ELBW infants--a single centre four year experience

Acta Paediatrica
Angela KribsB Roth

Abstract

To evaluate whether the experience with a method to administer surfactant during spontaneous breathing with nasal continuous positive airway pressure (nCPAP) as primary respiratory support in infants with respiratory distress syndrome (RDS) influences the frequency of its use and affects the outcome of patients. All inborn extremely low birthweight (ELBW) infants treated after introduction of the method were retrospectively studied (n=196). The entire observational period was divided into four periods (periods 1-4) and compared with a control period (period 0) (n=51). Primary respiratory support, demographics, prenatal risks and outcomes were compared. There were no changes in demographics or prenatal risks over time. The choice of nCPAP as initial airway management significantly increased from 69% to 91% and for nCPAP with surfactant from 75% to 86%. The rate of nCPAP failure decreased from 46% to 25%. Survival increased significantly between periods 0 and 1 from 76% to 90% and survival without bronchopulmonary dysplasia (BPD) rose from 65% to 80%. No changes in nonpulmonary outcomes were observed. The success of nCPAP increased with increasing use of nCPAP with surfactant. Simultaneously, mortality decreased without deteriora...Continue Reading

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Citations

Aug 8, 2013·Therapeutic Delivery·Nashwa El-GendyPrajnaparamita Dhar
Nov 21, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Carlo DaniGiovanna Bertini
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Jul 24, 2008·Acta Paediatrica·Ds Patel, A Greenough
Mar 21, 2012·Acta Paediatrica. Supplement·Kajsa Bohlin
Aug 19, 2015·Frontiers in Pediatrics·Theodora Katsila, George P Patrinos
Apr 8, 2015·Indian Pediatrics·M EibisbergerB Resch
Feb 13, 2013·Critical Care Research and Practice·Megan O'ReillyGeorg M Schmölzer
Oct 19, 2017·Korean journal of pediatrics·Gyu-Hong Shim
Apr 25, 2017·Clinical and Experimental Emergency Medicine·Dong Jin YangKyoung Soo Lim
Dec 13, 2016·European Journal of Pediatrics·Daniel KlotzHans Fuchs
Jan 13, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Dalibor KurepaVenkatakrishna Kakkilaya
Jan 27, 2021·Early Human Development·Hemant AmbulkarAnne Greenough
May 11, 2021·The Cochrane Database of Systematic Reviews·Mohamed E Abdel-LatifPeter A Dargaville
May 25, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yedidiel ElbazEric S Shinwell
Oct 3, 2021·NeoReviews·Scott O GuthrieKari D Roberts
Mar 21, 2012·Pediatrics·Gerhardus Francois KirstenJustin Harvey

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