Early surgical decompression within 8 hours for traumatic spinal cord injury: Is it beneficial? A meta-analysis

Acta orthopaedica et traumatologica turcica
Dong-Yeong LeeDong-Hee Kim

Abstract

The aim of this study is to evaluate whether early (<8 h) surgical decompression is better in improving neurologic outcomes than late (≥8 h) surgical decompression for traumatic spinal cord injury (tSCI). The various electronic databases were used to detect relevant articles published up until May 2016 that compared the outcomes of early versus late surgery for tSCI. Data searching, extraction, analysis, and quality assessment were performed according to Cochrane Collaboration guidelines. The results are presented as relative ratio (RR) for binary outcomes and mean difference (MD) for continuous outcomes with 95% confidence intervals (CIs). Seven studies were finally included in this meta-analysis. There were significant differences between the 2 groups in neurologic improvement (MD = 0.54, 95% CI = -18.52 to -7.02, P < 0.0001) and length of hospital stay (MD = -12.77, 95% CI = 0.34-0.74, P < 0.00001). However, no significant differences were found between the 2 groups in perioperative complications (OR = 0.95, 95% CI = 0.35-2.61, P = 0.92). Early surgical decompression within 8 h after tSCI was beneficial in terms of neurologic improvement compared with late surgery. Early surgical decompression (within 8 h) is recommended for...Continue Reading

References

Jul 1, 1995·The Journal of Bone and Joint Surgery. American Volume·R B DelamarterJ B Carr
Jun 6, 1998·Experimental Neurology·S L CarlsonL Dossett
Apr 13, 2000·Spinal Cord·V PointillartP Dabadie
Nov 3, 2004·Archives of Physical Medicine and Rehabilitation·William McKinleyBarbara Barnard
Jan 28, 2005·Journal of Neurotrauma·Alun AckeryAndrei Krassioukov
Jan 28, 2005·The Journal of Trauma·Andrew J KerwinJoseph J Tepas
Aug 3, 2007·Neuroscience Letters·Tiziana GenoveseSalvatore Cuzzocrea
Aug 22, 2007·Journal of Orthopaedic Surgery·G S Sapkas, S A Papadakis
Sep 13, 2008·The International Journal of Neuroscience·Vafa Rahimi-MovagharMohammad Hosein Nabian
Nov 11, 2010·Annals of the New York Academy of Sciences·Weiping QinChristopher Cardozo
Jan 29, 2011·Spine·Leah Y Carreon, John R Dimar
Sep 19, 2012·Journal of Neurosurgery. Spine·Robert G GrossmanJames S Harrop
May 1, 2011·Evidence-based Spine-care Journal·Michael J H McCarthyRichard Williams
Sep 5, 2014·Asian Spine Journal·Muhammad Sohail UmeraniSalman Sharif
Jan 13, 2015·International Orthopaedics·Yang LiuWen Yuan
Feb 26, 2016·Spine·Najib E El TeclePatrick W Hitchon

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Citations

Apr 2, 2020·Anaesthesia Critical Care & Pain Medicine·A RoquillyH Quintard
Jan 7, 2021·Neurospine·Jutty ParthibanSalman Yousuf Sharif
Nov 17, 2020·Spine Surgery and Related Research·Ahmed BakhshHany Eldawoody
Mar 16, 2021·Journal of Clinical Orthopaedics and Trauma·Rishi Mugesh KannaS Rajasekaran
Mar 23, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tushar Narayan RathodAbhinandan Reddy Mallepally
Jun 15, 2021·Journal of Family Medicine and Primary Care·Ibrahim AlnaamiMohammed Abid Khan
Jun 12, 2021·Journal of Neurosurgical Sciences·Ryan R PhelpsSanjay S Dhall
Dec 8, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Colby OitmentMark Pahuta

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