PMID: 2937825Apr 1, 1986Paper

Early thrombolysis in acute myocardial infarction: limitation of infarct size and improved survival

Journal of the American College of Cardiology
M L SimoonsA van der Laarse

Abstract

The effect of thrombolysis in acute myocardial infarction on infarct size, left ventricular function, clinical course and patient survival was studied in a randomized trial comparing thrombolysis (269 patients) with conventional treatment (264 control patients). All 533 patients were admitted to the coronary care unit within 4 hours after the onset of symptoms related to the infarction. Baseline characteristics were similar in both groups. Informed consent was requested only of patients allocated to thrombolysis; no angiography was performed in 35. The infarct-related artery was patent in 65 patients and occluded in 169. Recanalization was achieved in 133 patients. The median time to angiographic documentation of vessel patency was 200 minutes after the onset of symptoms. The clinical course in the coronary care unit was more favorable after thrombolysis. Infarct size, estimated from myocardial enzyme release, was 30% lower after thrombolysis. In patients admitted within 1 hour after the onset of symptoms the reduction of infarct size was 51%, in those admitted between 1 and 2 hours it was 31% and in those admitted later than 2 hours it was 13%. Left ventricular function measured by radionuclide angiography before hospital disc...Continue Reading

References

May 31, 1979·The New England Journal of Medicine·M Zelen
Apr 1, 1986·Journal of the American College of Cardiology·P W SerruysW J Remme
Jun 2, 1983·The New England Journal of Medicine·J L AndersonA D Hagan
Dec 15, 1983·The New England Journal of Medicine·J W KennedyJ K Fritz
Mar 8, 1984·The New England Journal of Medicine·F Van de WerfB E Sobel
Sep 1, 1983·Clinical Cardiology·K L NeuhausH Köstering
Apr 5, 1984·The New England Journal of Medicine·W C Hsiao
Jul 1, 1984·The American Journal of Cardiology·E L AldermanM Eliastam
May 21, 1981·The New England Journal of Medicine·J E MullerE Braunwald
Apr 1, 1983·Journal of the American College of Cardiology·S G EllisR A Kloner
Oct 16, 1980·The New England Journal of Medicine·M A DeWoodH T Lang

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Citations

May 28, 2008·Archives of Internal Medicine·Kathleen DracupSteven M Paul
Sep 1, 1990·Clinical Cardiology·D MasselJ A Cairns
Nov 1, 1992·Clinical Cardiology·P Jain, S C Vlay
Sep 1, 1995·Clinical Cardiology·B M Friedman, M I Dunn
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·M SaeedC B Higgins
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SaeedC B Higgins
May 1, 1988·Cardiovascular Drugs and Therapy·J Schaper, W Schaper
May 1, 1988·Cardiovascular Drugs and Therapy·P J de FeyterP G Hugenholtz
Oct 1, 1994·Annals of Hematology·D C Gulba, R Dechend
Sep 1, 1987·Progress in Cardiovascular Diseases·H F Weisman, B Healy
Jan 1, 1995·La Revue de médecine interne·G GrollierJ C Potier
Feb 1, 1995·Social Science & Medicine·K DracupA Braslow
Apr 1, 1988·Journal of the American College of Cardiology·J L RitchieJ W Kennedy
Dec 1, 1988·Journal of the American College of Cardiology·D B MarkR M Califf
Dec 1, 1988·Journal of the American College of Cardiology·E R Bates
Aug 1, 1989·Journal of the American College of Cardiology·R ErbelJ Meyer
May 1, 1989·Journal of the American College of Cardiology·A Selzer
Nov 1, 1989·Journal of the American College of Cardiology·K KanamasaW Ganz
Jul 1, 1990·Journal of the American College of Cardiology·C L Grines, A N DeMaria
Sep 1, 1991·Journal of the American College of Cardiology·J J de VreedeH J Wellens
Oct 1, 1992·Journal of the American College of Cardiology·A L TaylorR Eckels
Dec 1, 1992·Journal of the American College of Cardiology·M D CerqueiraJ W Kennedy
Nov 1, 1993·Journal of the American College of Cardiology·T LindererJ Wagner

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