Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial

Lancet
Mark F CottonCHER Study Team

Abstract

Interim results from the children with HIV early antiretroviral (CHER) trial showed that early antiretroviral therapy (ART) was life-saving for infants infected with HIV. In view of the few treatment options and the potential toxicity associated with lifelong ART, in the CHER trial we compared early time-limited ART with deferred ART. CHER was an open-label randomised controlled trial of HIV-infected asymptomatic infants younger than 12 weeks in two South African trial sites with a percentage of CD4-positive T lymphocytes (CD4%) of 25% or higher. 377 infants were randomly allocated to one of three groups: deferred ART (ART-Def), immediate ART for 40 weeks (ART-40W), or immediate ART for 96 weeks (ART-96W), with subsequent treatment interruption. The randomisation schedule was stratified by clinical site with permuted blocks of random sizes to balance the numbers of infants allocated to each group. Criteria for ART initiation in the ART-Def group and re-initiation after interruption in the other groups were CD4% less than 25% in infancy; otherwise, the criteria were CD4% less than 20% or Centers for Disease Control and Prevention severe stage B or stage C disease. Combination therapy of lopinavir-ritonavir, zidovudine, and lamiv...Continue Reading

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Citations

Nov 20, 2013·Current Opinion in HIV and AIDS·Intira J CollinsDiana M Gibb
Jun 14, 2014·Journal of the International AIDS Society·Steve InnesMark F Cotton
Jul 20, 2014·Advances in Pediatrics·Daniel GonzalezMichael Cohen-Wolkowiez
Nov 25, 2014·Journal of the International AIDS Society·Mark F Cotton, Helena Rabie
Nov 12, 2013·Lancet·Robert Colebunders, Victor Musiime
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Jan 15, 2016·The Lancet. HIV·Helena Rabie, Mark F Cotton
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Dec 12, 2017·The Pediatric Infectious Disease Journal·Moherndran ArcharyStefanie Hennig
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