Early tissue incorporation and collagen deposition in lightweight polypropylene meshes: bioassay in an experimental model of ventral hernia

Surgery
G PascualJuan M Bellón

Abstract

This study was designed to assess the early host tissue incorporation of several polypropylene lightweight (PP-LW) meshes used to repair abdominal wall defects and to correlate collagen deposition with the biomechanical response shown by PP-LW versus polypropylene heavyweight (PP-HW) meshes. Ventral hernial defects (7 x 5 cm) were created in the anterior abdominal wall of New Zealand rabbits and repaired by fixing PP-LW mesh of different pore sizes or a low porosity HW mesh to the edges of the defect. Rabbits were killed 14 days after implant, and specimens were taken from the central mesh area to examine collagen deposition by light microscopy, real time reverse transcription polymerase chain reaction, immunohistochemistry, and Western blotting. The biomechanical resistance of the biomaterials was also assessed. All the materials showed excellent incorporation in host tissue. Relative amounts of collagen III mRNA were considerably higher than collagen I mRNA. Higher collagen I and III mRNA levels were noted for pore sizes equal to or greater than 3.45 +/- 0.19 mm(2) (Ultrapro/Optilene Elastic. These two meshes showed significantly higher levels of collagen III than Parietene and Surgipro with smaller pores. Biomechanical resis...Continue Reading

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Citations

Dec 29, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·C G Pereira-lucenaM M Linhares
Mar 11, 2010·Journal of Materials Science. Materials in Medicine·Gabriela VoskericianMichael J Rosen
May 9, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Sharon L EdwardsCaroline E Gargett
Mar 17, 2010·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M A T MuftuogluA Saglam
Mar 26, 2011·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M Á García UreñaC Zaragoza
Jun 30, 2012·Hernia : the Journal of Hernias and Abdominal Wall Surgery·G PascualJ M Bellón
Jan 25, 2013·Hernia : the Journal of Hernias and Abdominal Wall Surgery·L ZogbiM R M Trindade
Mar 21, 2012·International Urogynecology Journal·Hiren PatelGina Sternschuss
Feb 26, 2016·Journal of the Mechanical Behavior of Biomedical Materials·B CalvoJ M Bellón
Nov 30, 2015·Journal of the Mechanical Behavior of Biomedical Materials·S TodrosA N Natali
Nov 22, 2011·Journal of the Mechanical Behavior of Biomedical Materials·B Hernández-GascónB Calvo
Apr 25, 2009·Cirugía española·Juan M Bellón
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Aug 21, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shawn J PenistonShalaby W Shalaby
May 9, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gemma PascualJuan M Bellón
Nov 26, 2010·American Journal of Ophthalmology·Consuelo Pérez-RicoJulia Buján
Mar 24, 2015·Journal of the American College of Surgeons·William S CobbAlfredo M Carbonell
Nov 22, 2012·Computer Methods in Biomechanics and Biomedical Engineering·B Hernández-GascónB Calvo
Nov 14, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Mohammad MirjavanAli Asghar Asgharian Jeddi
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Aug 24, 2018·Plastic and Reconstructive Surgery·William S Cobb
Mar 30, 2017·Bioactive Materials·Surge KalabaJian Yang
Jun 3, 2021·Materials·Marta RodríguezJuan Manuel Bellón
Jun 17, 2021·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Carlos Alberto Lima UtraboOsvaldo Malafaia
Jul 13, 2021·Frontiers in Surgery·Xinsen XuLinhua Yang
May 23, 2021·Journal of Biomedical Materials Research. Part a·Ángel Serrano-Aroca, Salvador Pous-Serrano

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