Early toxic effect of 6-hydroxydopamine on extracellular concentrations of neurotransmitters in the rat striatum: an in vivo microdialysis study

Neurotoxicology
Julio César Tobón-VelascoAbel Santamaría

Abstract

The early effects of 6-OHDA as a Parkinsonian model in rodents are relevant since pharmacological and toxicological points of view, as they can explain the acute and chronic deleterious events occurring in the striatum. In this study, we focused our attention on the neurochemical and motor dysfunction produced after a pulse infusion of 6-OHDA, paying special attention to the capacity of this molecule to induce neurotransmitter release and behavioural alterations. Extracellular levels of dopamine, serotonin, norepinephrine, glutamate, glutamine, aspartate, glycine and GABA were all assessed in striatal dialysates in freely moving rats immediately after exposed to a single pulse of 6-OHDA in dorsal striatum, and major behavioural markers of motor alterations were simultaneously explored. Enhanced release of dopamine, serotonin and norepinephrine was found immediately after 6-OHDA pulse. Delayed glutamate and glycine release were detected and a biphasic effect on GABA was observed. Mostly serotonin and dopamine outflow, followed by glutamate, correlated with wet dog shakes and other behavioural qualitative alterations. Early dopamine release, accompanied by other neurotransmitters, can generate an excitatory environment affecting ...Continue Reading

References

Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
Mar 16, 1995·European Journal of Pharmacology·Y Y Glinka, M B Youdim
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Jun 1, 2000·Journal of Inorganic Biochemistry·W Linert, G N Jameson
May 2, 2001·Parkinsonism & Related Disorders·L L. DuganK L. O'Malley
Jun 14, 2002·Experimental Neurology·Ronald DeumensJos Prickaerts
Sep 10, 2002·Parkinsonism & Related Disorders·Michael J ZigmondRuth G Perez
Oct 27, 2004·Cell and Tissue Research·Andreas Schober
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi BovéSerge Przedborski
Apr 20, 2006·The Journal of Biological Chemistry·Elisabeth M ChalovichCharleen T Chu
Nov 19, 2008·Parkinsonism & Related Disorders·Eleni Koutsilieri, Peter Riederer
Jul 4, 2008·Parkinsonism & Related Disorders·Fabio BlandiniEmilia Martignoni
Jun 3, 2009·Brain, Behavior, and Immunity·Sondra T BlandKirk W Johnson

❮ Previous
Next ❯

Citations

May 13, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sheng ZhangYong-Qi Fang
Nov 11, 2017·Neurotoxicity Research·Maricela Dircio-BautistaAbel Santamaría

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.