Early transmission and case fatality of Ebola virus at the index site of the 2013-16 west African Ebola outbreak: a cross-sectional seroprevalence survey.

The Lancet Infectious Diseases
Joseph W S TimothyMiles W Carroll

Abstract

To date, epidemiological studies at the index site of the 2013-16 west African Ebola outbreak in Meliandou, Guinea, have been restricted in their scope. We aimed to determine the occurrence of previously undocumented Ebola virus disease (EVD) cases and infections, and to reconstruct transmission events. This cross-sectional seroprevalence survey of the adult population of Meliandou used a highly specific oral fluid test and detailed interviews of all households in the village and key informants. Each household was interviewed, with all members prompted to describe the events of the outbreak, any illness within the household, and possible contact with suspected cases. Information for deceased individuals was provided by relatives living in the same household. Symptoms were based on Ebola virus Makona variant EVD case definitions (focusing on fever, vomiting, and diarrhoea). For antibody testing, we used an Ebola virus glycoprotein IgG capture enzyme immunoassay developed from a previously validated assay. A maximum exposure level was assigned to every participant using a predetermined scale. We used a generalised linear model (logit function) to estimate odds ratios for the association of sociodemographic variables and exposure ...Continue Reading

Citations

Mar 28, 2019·Expert Review of Molecular Diagnostics·John TemboMatthew Bates
Feb 23, 2020·BMJ : British Medical Journal·Lisa F P Ng, Julian A Hiscox
Feb 23, 2020·Nature Reviews. Disease Primers·Shevin T JacobJens H Kuhn
Aug 7, 2021·Current Opinion in Pharmacology·Elijah Ige Ohimain

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent

Software Mentioned

RStudio
EpiData
lmtest
glm
epiR

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