Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

Neural Regeneration Research
Min Cheol ChangDae-Yul Kim

Abstract

The neuroprotective function of macrophage migration inhibitory factor (MIF) in ischemic stroke was rarely evaluated. This study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor (BDNF) in the ischemic area. A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion (MCAO)-Ex, n = 10), ischemia and sedentary group (MCAO-St, n = 10), sham-surgery and exercise group (Sham-Ex, n = 10), or sham-surgery and sedentary group (Sham-St, n = 10). The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes, whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without MCAO. Rats in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive days. After reperfusion, the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St group. The expression levels of MIF and BDNF in the peri-infarct regi...Continue Reading

References

Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·R I LindleyP A Sandercock
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·M S DennisC P Warlow
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mai Tuyet NguyenJürgen Bernhagen
Sep 23, 2003·Nature Reviews. Immunology·Thierry Calandra, Thierry Roger
Dec 1, 2007·Journal of Magnetic Resonance Imaging : JMRI·Jeffrey J Neil
Dec 25, 2007·Journal of Molecular Neuroscience : MN·Yaniv Assaf, Ofer Pasternak
Jan 5, 2008·Stroke; a Journal of Cerebral Circulation·Julie BernhardtGeoffrey Donnan
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Brad R S BroughtonChristopher G Sobey
Apr 21, 2009·Methods in Molecular Biology·Masanori SasakiJeffery D Kocsis
Jul 14, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Junichi Miyamoto, Katsuyoshi Mineura
Nov 11, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ana R InácioTomas Deierborg
Apr 30, 2013·Journal of Neuroengineering and Rehabilitation·Pengyue ZhangYongshan Hu
Jun 28, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Si ZhangWeihong Song
Feb 11, 2015·Current Medicinal Chemistry·Masahito Kawabori, Midori A Yenari
Dec 16, 2016·American Journal of Physical Medicine & Rehabilitation·Liqiang YangPengyue Zhang
Jan 13, 2017·Journal of Clinical Neurology·Simone VidaleDomenico Consoli
May 24, 2017·Nature Communications·Cecilie MorlandLinda H Bergersen
Nov 9, 2017·Current Atherosclerosis Reports·Elisheva R ColemanWuwei Feng

❮ Previous
Next ❯

Software Mentioned

SPSS
Analysis of Functional NeuroImages AFNI
Leica Application Suite
Diffusion Toolkit
MCID

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.