Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival

Neuro-oncology
Ryan AlkinsKullervo Hynynen

Abstract

Malignant brain tumors have a dismal prognosis, with residual tumor remaining after surgery necessitating adjuvant chemoradiotherapy. The blood-brain barrier hinders many chemotherapeutic agents, resulting in modest treatment efficacy. We previously demonstrated that targeted natural killer (NK)-92 cells could be delivered to desired regions of the brain using MRI-guided focused ultrasound and Definity microbubbles. Targeted NK-92 cells have advantages over many systemic therapies including their specific cytotoxicity to malignant cells (particularly those expressing the target antigen), ability to spare healthy cells, and being unaffected by efflux channels. We investigated whether longitudinal treatments with targeted NK-92 cells, focused ultrasound, and microbubbles could slow tumor growth and improve survival in an orthotopic HER2-amplified rodent brain tumor model using a human breast cancer line as a prototype. The HER2 receptor, involved in cell growth and differentiation, is expressed by both primary and metastatic brain tumors. Breast cancers with HER2 amplification have a higher risk of CNS metastasis and poorer prognosis. Early intensive treatment with targeted NK-92 cells and ultrasound improved survival compared wi...Continue Reading

References

Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R MiralbellR O Mirimanoff
Dec 15, 2000·Medical Oncology·W A HallK H Cho
Nov 5, 2002·Nature Reviews. Cancer·Mark J SmythHideo Yagita
Oct 31, 2003·Cancer Treatment Reviews·Roy A Patchell
Aug 18, 2004·Ultrasound in Medicine & Biology·Nickolai SheikovKullervo Hynynen
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Dec 24, 2005·Nature Reviews. Neuroscience·N Joan AbbottElisabeth Hansson
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie L MuldoonEdward A Neuwelt
Jun 16, 2007·Journal of Neuro-oncology·Jean-François MineoPhong Dam Hieu
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giulio FranciaRobert S Kerbel
Sep 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun-Joo ParkNathan McDannold
Jan 11, 2013·Cancer Research·Ryan AlkinsKullervo Hynynen

❮ Previous
Next ❯

Citations

Aug 9, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thiele KobusNathan J McDannold
Apr 11, 2017·Annals of Neurology·Ying MengNir Lipsman
Jun 27, 2017·Advanced Drug Delivery Reviews·Vasileios AskoxylakisRakesh K Jain
Jun 16, 2017·Journal of Central Nervous System Disease·Paul S Fishman, Victor Frenkel
Aug 5, 2017·Immunotherapy·Wan-Ning WangWen-Long Zhang
Feb 2, 2018·Neurosurgical Focus·Layton LamsamMelanie Hayden Gephart
Nov 13, 2018·Expert Opinion on Drug Delivery·Sofie SnipstadTwan Lammers
Mar 1, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Paul S Fishman, Victor Frenkel
Mar 3, 2018·Frontiers in Immunology·Rohtesh S Mehta, Katayoun Rezvani
Jan 17, 2019·International Journal of Molecular Sciences·Jianguang ZhangYong Diao
May 16, 2020·Journal of Immunology Research·Chaopin YangZhiyi Chen
Feb 23, 2019·Journal of Neuro-oncology·Bridget A KennisVidya Gopalakrishnan
Oct 17, 2017·Journal of Therapeutic Ultrasound·Ying MengNir Lipsman
Dec 9, 2020·Journal of Hematology & Oncology·Ahmet YilmazJianhua Yu
Jul 22, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying MengNir Lipsman
Oct 28, 2020·Nature Reviews. Neurology·Ying MengNir Lipsman
Dec 31, 2020·Pharmaceutics·Sheng-Kai WuKullervo Hynynen
Mar 14, 2020·Ultrasound in Medicine & Biology·Klazina KooimanChristy K Holland
May 1, 2021·Pharmaceutics·Kwang-Soo KimDong-Hyun Kim
Jun 29, 2021·Advanced Drug Delivery Reviews·Sofie SnipstadCatharina de Lange Davies
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
May 26, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aria SabbaghAmy B Heimberger
Dec 12, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jean-Michel Escoffre, Ayache Bouakaz
Nov 12, 2021·Current Protocols·Mohini SinghPriscilla K Brastianos

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.