PMID: 11897986Mar 19, 2002Paper

Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long-term outcome

The Journal of Allergy and Clinical Immunology
Juhani RinneTari Haahtela

Abstract

Perennial rhinitis is a common disease that has many similarities with bronchial asthma. Early treatment with inhaled steroids has improved asthma symptoms, lung function, and bronchial hyperreactivity, but it has not been studied in perennial rhinitis. The main objective was to determine whether early introduction of long-term daily intranasal steroid treatment would have a positive effect on the clinical course and outcome of perennial rhinitis compared with the effect of an antihistamine. A secondary objective was to compare the clinical efficacy of intranasal budesonide and oral cetirizine. One hundred forty-three adult patients with newly detected perennial allergic or nonallergic eosinophilic rhinitis of 1 to 3 years' duration were randomized to receive budesonide dry powder, 400 microg (delivered dose of 280 microg) intranasally, or cetirizine, 10 mg orally, once daily for 1 year. At the end of the double-blind treatment period, medication was stopped, and the patients were followed for another year, during which time they could use 14-day courses of intranasal budesonide as needed to control rhinitis relapses. The main outcome measures were the time to first relapse and the number of relapses during the second year. Nas...Continue Reading

Citations

Aug 23, 2006·Acta Oto-laryngologica·Niels Mygind, Morgan Andersson
Oct 11, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John H KrouseDarrell Hunsaker
Apr 10, 2014·Current Allergy and Asthma Reports·Phil Lieberman, Debendra Pattanaik
Jan 23, 2016·Expert Opinion on Pharmacotherapy·Ludger KlimekWytske Fokkens
Feb 24, 2004·Drugs·Monique P CurranCaroline M Perry
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