Early tumour shrinkage as a prognostic factor and surrogate end-point in colorectal cancer: a systematic review and pooled-analysis

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
F PetrelliS Barni

Abstract

Early tumour shrinkage (ETS), defined as a reduction of at least 20% in tumour size at first reassessment, has been recently investigated retrospectively in first-line trials of metastatic colorectal cancer (CRC), and appears to be associated with better outcomes. We have performed a systematic review and meta-analysis of published trials to evaluate the prognostic value of ETS in CRC in terms of overall survival (OS) and progression-free survival (PFS). An electronic search of the PubMed, SCOPUS, EMBASE, the Web of Science, and the Cochrane Central Register of Controlled Trial databases identified trials that compared outcomes of patients with or without ETS during first-line chemotherapy for metastatic CRC. The OS, reported as a hazard ratio (HR) with a 95% confidence interval (CI), was the primary outcome measure; the correlation coefficient (R) between ETS with median OS was also estimated. Twenty-one trials from 10 publications were analysed. Overall, patients with ETS were associated with a better OS (HR, 0.58; 95% CI, 0.53 to 0.64; P<0.00001) and PFS (HR, 0.57; 95% CI, 0.47-0.69; P<0.00001) compared with patients who were early non-responders. However, ETS was poorly correlated with OS in terms of surrogacy (R=0.37; 95% ...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Feb 3, 2006·Biometrical Journal. Biometrische Zeitschrift·José Cortiñas Abrahantes, Tomasz Burzykowski
Sep 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia A TangLillian L Siu
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc BuysePascal Piedbois
Aug 13, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SuzukiB Glimelius
Feb 22, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stéphane OudardCharles A Cuenod
Aug 18, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Petrelli, S Barni
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hubert PiessevauxSabine Tejpar
Jan 15, 2014·Clinical Pharmacology and Therapeutics·R BrunoL Claret

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Citations

Nov 18, 2015·Expert Opinion on Drug Metabolism & Toxicology·Louisa LoTimothy J Price
Mar 25, 2016·Expert Review of Anticancer Therapy·Timothy J PriceJeremy D Shapiro
May 22, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R García-CarboneroF Matute
Sep 7, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Volker HeinemannJean-Yves Douillard
Oct 14, 2016·The Lancet Oncology·Michael Davidson, Ian Chau
Oct 22, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mohamed BouchahdaUNKNOWN ARTBC International
Nov 20, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Chiara CremoliniM Di Maio
Aug 12, 2018·International Journal of Cancer. Journal International Du Cancer·Nandita M deSouza, Clare M Tempany
Mar 7, 2020·World Journal of Clinical Oncology·Nuri Faruk Aykan, Tahsin Özatlı
Feb 2, 2019·European Radiology·Lola-Jade PalmieriJean-Baptiste Bachet
Feb 6, 2019·International Journal of Clinical Oncology·Giuseppe A CollocaDomenico Guarneri
Sep 21, 2019·JAMA Network Open·Tomasz BurzykowskiUNKNOWN Aide et Recherche en Cancerologie Digestive Group
Dec 16, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Paolo MancaFilippo Pietrantonio

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