Early ultrastructural changes in the myocardium following thyroxine-induced hypertrophy

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
C Craft-Cormney, J T Hansen

Abstract

The model of myocardial hypertrophy induced by thyroxine was studied with particular regard to the early ultrastructural changes in fractional volume of the mitochondria and myofibrils, and capillary distribution. Following injections of L-thyroxine (25 mg/kg IP) for 9 consecutive days, rats were sacrificed by vascular perfusion and cardiac tissue samples from the mid-wall zone of the left ventricle were processed routinely for electron microscopy. Heart weight/body weight ratios of thyroxine treated (T) rats showed a significant increase (P less than 0.001) over the ratios in control (C) rats. Likewise, the fractional volume of mitochondria (42%) was significantly increased (P less than 0.001) in the myocardium of T rats when compared with C rats (31%). However, the fractional volume of myofibrils was significantly decreased in the myocardium of T rats (P less than 0.001) and there was no significant difference between the hearts of T and C rats with respect to capillary luminal area/myocyte area. The mitochondria/myofibril ratio was increased in the hearts of T rats (0.82) over that found in control hearts (0.52). These results suggest that in the early stages of thyroxine-induced myocardial hypertrophy there is not an immedi...Continue Reading

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Citations

Jan 26, 2005·Virchows Archiv : an International Journal of Pathology·Li Wen HuMaria Luiza Morais Barreto-Chaves
Jan 28, 2006·Virchows Archiv : an International Journal of Pathology·Luana Anjos-RamosMaria Luiza Morais Barreto-Chaves
Aug 28, 2014·Journal of Structural Biology·Matthew S SulkinIgor R Efimov
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Roy E WeissRoberto Lang
May 30, 1998·The Anatomical Record·R J Tomanek, T L Busch

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