Abstract
Previous studies suggest that both overfeeding and undernutrition during development increase the risk of obesity and hypertension in adulthood. In this study, we examined both short- (24 d) and long- (16 wk) term effects of early postnatal over- and underfeeding in rats on body weight, body composition, plasma hormones, adiposity markers, and hypothalamic neuropeptide Y content. Cardiovascular changes were also examined by measuring blood pressure and cardiac fibrosis. Rats raised in litters of 3, 12, or 18 pups per mother were used to model early onset overfeeding, control, and underfeeding, respectively. At 24 d of age, pups raised in small litters (SL) were 10% heavier than pups from normal litters, accompanied by increased organ mass and fat mass, elevated plasma leptin, corticosterone, and uncoupling protein-1 mRNA in brown adipose tissue. On the other hand, pups raised in large litters were 17% lighter with no significant changes in plasma leptin. Overfeeding during the first 3 wk of life led to increased plasma leptin concentration in adulthood, whereas underfed rats remained significantly lighter throughout the study, with no evidence of catch-up growth. Rats raised in SL were more susceptible to developing cardiac fib...Continue Reading
References
Feb 1, 1978·Circulation Research·K RakusanB Korecky
Feb 1, 1992·Journal of Hypertension·A F Lever, S B Harrap
Feb 1, 1991·The American Journal of Physiology·C J BillingtonA S Levine
Oct 1, 1986·Journal of the Autonomic Nervous System·M J MorrisJ P Chalmers
Jul 1, 1984·Endocrinology·J T ClarkS P Kalra
Mar 1, 1984·The American Journal of Physiology·R T Dowell
Jul 28, 1995·Science·J L HalaasJ M Friedman
Dec 5, 1994·Brain Research·A AkabayashiS F Leibowitz
Feb 5, 1998·Molecular and Cellular Biochemistry·V PelouchB Ostádal
Apr 16, 1998·The Journal of Clinical Investigation·R S AhimaJ S Flier
Aug 14, 1998·European Journal of Endocrinology·O BossJ P Giacobino
Sep 2, 1998·Endocrinology·K ArvanitiD Richard
Aug 12, 1999·Journal of Neuroendocrinology·A PlagemannG Dörner
Oct 6, 1999·Molecular and Cellular Endocrinology·T J ColeM J Fullerton
Dec 29, 1999·Brain Research·D G BaskinM W Schwartz
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Feb 15, 2001·Brain Research·M J HansenM J Morris
Apr 20, 2001·The American Journal of the Medical Sciences·M A Alpert
Sep 5, 2002·The British Journal of Nutrition·Petra WiedmerSylvia Ortmann
Oct 5, 2002·Hypertension·Jonathan Sorof, Stephen Daniels
Nov 26, 2002·Endocrinology·Karine ProulxClaire-Dominique Walker
Feb 1, 2003·Neuroscience·K L GroveM S Smith
Jun 24, 2003·Physiology & Behavior·Kevin L Grove, M Susan Smith
Sep 29, 1962·Lancet·R A MCCANCE
Feb 6, 2004·Journal of Neurochemistry·Michelle J HansenMargaret J Morris
Apr 6, 2004·Science·Sebastien G BouretRichard B Simerly
Dec 24, 2004·Diabetes·Sandrine Boullu-CioccaMichel Grino
Dec 24, 2004·Diabetologia·M LópezR M Señarís
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Elena VelkoskaMargaret J Morris
Feb 12, 2005·The Journal of Physiology·I Caroline McMillenBeverly S Mühlhäusler
Feb 24, 2005·Brain Research·Sarah F LeibowitzGuo-Qing Chang
Dec 2, 2006·Endocrinology·Makoto KawamuraShingo Fujii
Dec 21, 2006·Circulation·Atul SinghalAlan Lucas
May 26, 2007·Endocrinology·Xiao Qiu XiaoKevin L Grove
Dec 7, 2007·The New England Journal of Medicine·Jennifer L BakerThorkild I A Sørensen
Jan 2, 2008·Pediatrics·Haidong ZhuYanbin Dong
Citations
Jan 29, 2011·The British Journal of Nutrition·Natália da Silva LimaPatricia Cristina Lisboa
Jul 27, 2011·PloS One·Andreas F KolbC Bruce A Whitelaw
Sep 25, 2015·Lipids·Adriana Corona-PérezLeticia Nicolás-Toledo
Aug 9, 2016·Current Opinion in Lipidology·Elena Loche, Susan E Ozanne
Dec 1, 2017·PloS One·Mariel PinskyRoee Gutman
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Margaret J Morris
Jun 4, 2011·PloS One·Xue-Ying ZhangDe-Hua Wang
Apr 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael D RobertsFrank W Booth
Nov 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C J StockerJ R S Arch
Oct 13, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Umberto SimeoniFarid Boubred
Nov 16, 2013·Pediatric Research·Hyung Eun YimJoo Won Lee
Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hans-Rudolf BerthoudAndrew C Shin
Aug 1, 2012·The Journal of Endocrinology·Miao HouXiaonan Li
Dec 10, 2015·Immunology and Cell Biology·Agnieszka Mika, Monika Fleshner
Oct 1, 2016·Journal of Developmental Origins of Health and Disease·H DickinsonJ L Morrison
Mar 15, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Carlos F AylwinAlejandro Lomniczi
Jan 16, 2020·Nutrients·Guillaume BlinBenazir Siddeek
May 6, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Liou SunJames M Harper
Nov 11, 2011·PloS One·Miao HouXiaonan Li
Mar 1, 2013·The Journal of Nutrition·Ahmed HabboutCatherine Vergely
Nov 16, 2012·The Journal of Endocrinology·Júlio Cezar de OliveiraPaulo Cezar de Freitas Mathias
Apr 19, 2012·American Journal of Physiology. Endocrinology and Metabolism·Esther Fuente-MartínJulie A Chowen
Aug 26, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyung Eun Yim, Kee Hwan Yoo
Feb 18, 2017·Nutrients·Sonja StutteJoachim Woelfle
Feb 6, 2013·PloS One·Miriam GranadoAngel Luis García-Villalón
Sep 28, 2013·International Journal of Nephrology·F BoubredU Simeoni
Nov 17, 2015·Pediatric Research·Yessoufou AliouShao-Ling Zhang
Mar 12, 2019·Cell Death Discovery·Benazir SiddeekUmberto Simeoni
Jul 12, 2014·BioMed Research International·Lingxing WangZhenhua Wang
Sep 27, 2015·European Journal of Nutrition·Danielle T ReidRaylene A Reimer
Dec 17, 2020·International Journal of Molecular Sciences·Marie JosseCatherine Vergely
Aug 20, 2020·Cell Metabolism·Marcela Parra-VargasJosep C Jimenez-Chillaron
Oct 2, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Hamza AnwerMalgorzata Lagisz