Early vascular damage from smoking and alcohol in teenage years: the ALSPAC study.

European Heart Journal
Marietta CharakidaJohn E Deanfield

Abstract

To determine the impact of smoking and alcohol exposure during adolescence on arterial stiffness at 17 years. Smoking and alcohol use were assessed by questionnaires at 13, 15, and 17 years in 1266 participants (425 males and 841 females) from the ALSPAC study. Smoking status (smokers and non-smoker) and intensity ('high' ≥100, 'moderate' 20-99, and 'low or never' <20 cigarettes in lifetime) were ascertained. Participants were classified by frequency (low or high) and intensity of drinking [light (LI <2), medium (MI 3-9), and heavy (HI >10 drinks on a typical drinking day)]. Carotid to femoral pulse wave velocity (PWV) was assessed at 17 years [mean ± standard deviation and/or mean difference (95% confidence intervals)]. Current smokers had higher PWV compared with non-smokers (P = 0.003). Higher smoking exposure was associated with higher PWV compared with non-smokers [5.81 ± 0.725 vs. 5.71 ± 0.677 m/s, mean adjusted difference 0.211 (0.087-0.334) m/s, P = 0.001]. Participants who stopped smoking had similar PWV to never smokers (P = 0.160). High-intensity drinkers had increased PWV [HI 5.85 ± 0.8 vs. LI 5.67 ± 0.604 m/s, mean adjusted difference 0.266 (0.055-0.476) m/s, P = 0.013]. There was an additive effect of smoking inte...Continue Reading

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Citations

Sep 1, 2018·European Heart Journal·Thomas MünzelAndreas Daiber
Oct 1, 2019·Alcoholism, Clinical and Experimental Research·Marcia RussellMaurizio Trevisan
Sep 13, 2019·European Heart Journal·Yanguo XinXiaojing Liu
Jan 7, 2020·European Heart Journal·Christian HeissVictor Aboyans
Mar 21, 2019·European Journal of Preventive Cardiology·Frédéric ChaguéMarianne Zeller
Nov 22, 2019·European Journal of Preventive Cardiology·Georgios GeorgiopoulosMarietta Charakida
Jan 21, 2019·European Heart Journal·Thomas F Lüscher
Jun 3, 2021·International Journal of Environmental Research and Public Health·Frédéric ChaguéMarianne Zeller

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