Early versus delayed cord clamping in small for gestational age infants and iron stores at 3 months of age - a randomized controlled trial

BMC Pediatrics
Abhishek ChopraKanwal Gujral

Abstract

Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamping (ECC) on serum ferritin at 3 months in SGA infants born at ≥35 weeks. The secondary objectives were to compare hematological parameters, clinical outcomes in neonatal period and growth at 3 months of age. All eligible infants with fetal growth restriction were randomized to two groups, DCC at 60 s or ECC group in which the cord was clamped immediately after birth. Total of 142 infants underwent randomization and subsequently 113 infants underwent definite inclusion. At 3 months, the median (IQR) serum ferritin levels were higher in DCC group, compared to ECC; 86 ng/ml (43.35-134.75) vs 50.5 ng/ml (29.5-83.5), p = 0.01. Fewer infants had iron deficiency in DCC group compared to ECC group; 9 (23.6%) vs 21 (47.7%), p = 0.03 [NNT being 4; 95% CI (2-25)].The proportion of infants with polycythemia was significantly higher in DCC group; 23 (41.81) % vs 12 (20.6%), p = 0.01. There was no difference in proportion of infants with...Continue Reading

Associated Clinical Trials

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Citations

Jan 19, 2019·Archives of Gynecology and Obstetrics·Jiachen TangYu Chen
Feb 7, 2020·Obstetrics and Gynecology·Matthew J R NudelmanDongli Song
Jun 17, 2019·Archives of Gynecology and Obstetrics·Yiyu QianYing Hua
Mar 20, 2019·BioMed Research International·Stefano BasilePierluigi Benedetti Panici
Jan 23, 2021·European Journal of Pediatrics·Kanhu Charan DigalSriparna Basu
Aug 7, 2021·Clinics in Perinatology·Ola Andersson, Judith S Mercer
Aug 14, 2021·American Journal of Obstetrics and Gynecology·Beth Ellen BrownUNKNOWN Canadian Preterm Birth Network Investigators
Dec 3, 2021·Obstetrics and Gynecology·Ryan M McAdams, Satyan Lakshminrusimha
Feb 27, 2021·Pediatrics·Judith GomersallUNKNOWN INTERNATIONAL LIAISON COMMITTEE ON RESUSCITATION NEONATAL LIFE SUPPORT TASK FORCE

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Methods Mentioned

BETA
SGA
cesarean section

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