Early versus late prophylactic cranial irradiation in patients with extensive small cell lung cancer

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Yi ChenShunchang Jiao

Abstract

Previous studies demonstrated that prophylactic cranial irradiation (PCI) significantly reduced the incidence of brain metastases in patients with extensive disease small cell lung cancer (ED-SCLC). However, the appropriate timing for PCI in treating ED-SCLC is still unclear. This study aimed to compare the effect and safety of early versus late PCI. Between November 2011 and July 2016, 103 patients with ED-SCLC were reviewed, receiving appropriate imaging tests to exclude brain metastases prior to cranial irradiation. Of these 103 patients, early PCI was performed in 47 patients and the other 56 patients received late PCI. The primary endpoint was the incidence of brain metastases. The progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were also assessed. Early PCI significantly lowered the risk of brain metastases, as compared to late PCI (p = 0.024). Additionally, multivariate analyses demonstrated that early PCI was a favorable independent predictor of the incidence of brain metastases. The PFS and OS of patients in the early and late PCI groups were comparable (PFS: 8.4 months vs. 7.5 months, p = 0.234; OS: 16.1 months vs. 15.2 months, p = 0.753). The AEs were generally acceptable in both grou...Continue Reading

References

Mar 1, 1981·Archives of Internal Medicine·R FeldT C Brown
Feb 1, 1995·Journal of the National Cancer Institute·R ArriagadaS Benhamou
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·R SuwinskiH R Withers
Oct 8, 2003·International Journal of Radiation Biology·R Suwinski, H R Withers
Mar 12, 2004·Critical Reviews in Oncology/hematology·Miklos SimonJohn R Murren
Jun 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roger StuppSerge Leyvraz
Aug 25, 2004·Cancer Treatment Reviews·Yu Jo ChuaDesmond Yip
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Aug 19, 2007·The New England Journal of Medicine·Ben SlotmanUNKNOWN EORTC Radiation Oncology Group and Lung Cancer Group
Sep 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark A Socinski, Jeffrey A Bogart
May 25, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Beata Sas-KorczyńskaEwa Wójcik
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Jun 9, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A RamlovM M Knap
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K ÖbergUNKNOWN ESMO Guidelines Working Group
Jul 3, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M FrühUNKNOWN ESMO Guidelines Working Group
Aug 3, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·A A WindsorM B Barton
Sep 9, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yi ChenShunchang Jiao
Jan 12, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ahsan S FarooqiRitsuko Komaki

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Citations

Sep 16, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Yawen ZhengLigang Xing
Aug 16, 2019·Current Opinion in Oncology·Riccardo SoffiettiRoberta Rudà

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