PMID: 2117206Jan 1, 1990Paper

Early versus late surfactant replacement therapy in severe respiratory distress syndrome

Lung
C P SpeerB Robertson

Abstract

26 preterm infants with severe respiratory distress syndrome (RDS) have been treated at different ages with a single dose of natural porcine surfactant (Curosurf, 200 mg/kg). Criteria for treatment included clinical and radiological signs of severe RDS (grade III-IV), requirement of artificial ventilation and an FiO2 greater than or equal to 0.6. Nineteen neonates have been subjected to early treatment (2-15 h of age, mean birth weight SD: 1201 +/- 387 g) and 7 patients to late treatment (greater than 15 h to 48 h of age, birth weight SD 1624 +/- 649 g). Average FiO2 before treatment was 0.88 in early-treated patients and 0.8 in late-treated patients, age at treatment was 4.6 h and 36 h, respectively (median). Both early- and late-treated infants exhibited an improvement in oxygenation (more than twofold increase of the PaO2/FiO2 ratio) within 5 minutes after initiation of therapy. Average duration of intermittent pressure ventilation was 15 days in the early treatment group and 19 days in the late treatment group. Total exposition to greater than 21% oxygen was 21 days in early-treated and 48 days in late-treated infants. Pneumothorax occurred in none of the patients. All early treated infants survived without signs of severe ...Continue Reading

References

Sep 25, 1986·The New England Journal of Medicine·T A MerrittM Pohjavuori

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Citations

Aug 21, 1992·Pharmaceutisch Weekblad. Scientific Edition·A Van der Kuy
Jun 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·B W Kramer
May 7, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·J Wirbelauer, C P Speer

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