Early virological and immunological events in Epstein-Barr virus infection

Current Opinion in Virology
Andrew D Hislop

Abstract

Epstein-Barr virus (EBV) is a γ-herpesvirus which establishes a chronic yet asymptomatic infection in humans. This saliva transmitted virus has a tropism for B lymphocytes, in which it establishes a latent infection, and epithelial cells where the virus replicates to produce infectious particles. Although the majority of infections are apparently benign, primary EBV infection can be associated with an acute febrile syndrome, infectious mononucleosis, while infection is also associated with the development of malignancies of B lymphocyte and epithelial origin. A better understanding how the virus replicates initially in the host and its control at this stage will lead to the development of rationally targeted interventions which potentially would prevent infection or modify infection associated disease.

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Citations

Nov 22, 2015·Current Opinion in Virology·Philip Stevenson
Oct 1, 2016·Current Opinion in Virology·Ann M Moormann, Jeffrey A Bailey
Jun 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·María López-MontañésMiguel López-Botet
Jul 29, 2016·Journal of Virology·Clara LawlerPhilip G Stevenson
Oct 30, 2019·Scientific Reports·Johan S NilssonLennart Greiff

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