Early visual symptom patterns in inherited retinal dystrophies

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Elena ProkofyevaEberhart Zrenner

Abstract

The present retrospective study compared initial visual symptom patterns in inherited retinal dystrophies (IRD) on the basis of records of 544 patients diagnosed with a wide variety of IRD at the Tuebingen University Eye Hospital from 2005 to 2008. Age at first onset of symptoms was noted, and the following clinical data were analyzed: visual acuity (VA), night vision disturbances, photophobia, onset of visual field defects, best corrected VA, and types of visual field defects. Median age at visual symptom onset was defined with 25th and 75th percentiles and compared in 15 IRD types. The main trends in VA changes in retinitis pigmentosa and cone-rod dystrophies were identified. This study was the first to combine disease history and clinical data analysis in such a wide variety of IRD. It showed that patterns of initial symptoms in IRD can provide extra clues for early differential diagnosis and inclusion of IRD patients in clinical trials.

References

Sep 1, 1992·Clinical Genetics·B PeterlinV Cerar
Dec 1, 1992·Ophthalmic Paediatrics and Genetics·L I van den BornE M Bleeker-Wagemakers
Oct 1, 1990·Human Genetics·J KaplanJ L Dufier
May 15, 1988·American Journal of Ophthalmology·J R HeckenlivelyJ J Oversier
Apr 15, 1999·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·H G KrumpaszkyH K Selbmann
Jul 11, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ulrich H M Spandau, Klaus Rohrschneider
Jun 11, 2003·Archives of Ophthalmology·David A R BessantAlan C Bird
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georg NagelErnst Bamberg
Apr 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Samuel G JacobsonJean Bennett
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja
Feb 3, 2007·Orphanet Journal of Rare Diseases·Christian P Hamel
May 25, 2007·Neuron·Stephanie SzobotaEhud Y Isacoff
Aug 29, 2007·Investigative Ophthalmology & Visual Science·Holger ProkischThomas Rosenberg
Oct 24, 2009·Journal of Neural Engineering·Thomas Stieglitz
Aug 11, 2010·Archives of Ophthalmology·Isabelle AudoChristina Zeitz
Nov 5, 2010·Proceedings. Biological Sciences·Eberhart ZrennerRobert Wilke
Nov 20, 2010·Investigative Ophthalmology & Visual Science·Katherine E TalcottJacque L Duncan
May 25, 2011·The Journal of Clinical Investigation·Manzar AshtariJean Bennett

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Citations

Feb 15, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Kathleen B Digre, K C Brennan
Nov 22, 2011·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Elena ProkofyevaEberhart Zrenner
Sep 4, 2012·The European Journal of Neuroscience·Keiichiro OkamotoDavid A Bereiter
Jul 18, 2018·Current Eye Research·Anne KurtenbachEberhart Zrenner
Dec 23, 2019·Italian Journal of Pediatrics·Agnese SuppiejRaffaele Falsaperla
Oct 13, 2020·Cephalalgia : an International Journal of Headache·Andrew J ZeleBeatrix Feigl
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Fleur O'HareLauren N Ayton

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