Early weaning influences short-term synaptic plasticity in the medial prefrontal-anterior basolateral amygdala pathway

Neuroscience Research
Masatoshi Takita, Takefumi Kikusui

Abstract

Early weaning in rodents reportedly influences behavioral and emotional traits and triggers precocious myelin formation in the anterior basolateral amygdala (aBLA; Ono et al., 2008), where prefrontal efferents terminate. We studied the correlation between behavior and the synaptic properties of the prefrontal-aBLA pathway. Open-field behaviors of adult male rats weaned at either 16 days or 30 days were measured on two consecutive days. On the first day, the rats received a slight footshock that was reportedly insufficient for fear conditioning. Electrophysiological recordings in the prefrontal-aBLA were then performed under urethane anesthesia. Without group differences in the stimulus intensity or the first evoked response, the overall paired-pulse facilitation was significantly lower in the early-weaned group from 25 to 100 ms. At the 25-ms interval, regression values between paired-pulse facilitation and locomotion on the second day were positive/insignificant and negative/significant in early- and control-weaned groups, respectively, and were statistically different between the groups.

References

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Citations

Feb 6, 2017·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takefumi Kikusui, Kazutaka Mogi
Jul 2, 2016·Developmental Psychobiology·Takefumi KikusuiKazutaka Mogi
Jul 4, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Karoline Dos Santos RodriguesCristiane Matté
Feb 6, 2020·Neuroscience Research·Itsuka KamimuraTakefumi Kikusui
Aug 24, 2021·Developmental Psychobiology·Malaz KreikerKevin L Brown

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