Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study

Neurology
Kirsten CummingCarl E Counsell

Abstract

To compare weight change over time in patients with Parkinson disease (PD), those with atypical parkinsonism, and matched controls; to identify baseline factors that influence weight loss in parkinsonism; and to examine whether it predicts poor outcome. We analyzed data from the Parkinsonism Incidence in North-East Scotland (PINE) study, an incident, population-based prospective cohort of parkinsonian patients and age- and sex-matched controls with annual follow-up. Mixed-model analysis described weight change in patients with PD, those with atypical parkinsonism, and controls. Baseline determinants of sustained clinically significant weight loss (>5% loss from baseline) and associations between early sustained weight loss and death, dementia, and dependency in parkinsonism were studied with Cox regression. A total of 515 participants (240 controls, 187 with PD, 88 with atypical parkinsonism) were followed up for a median of 5 years. At diagnosis, atypical parkinsonian patients had lower body weights than patients with PD, who were lighter than controls. Patients with PD lost weight more rapidly than controls, and weight loss was most rapid in atypical parkinsonism. After multivariable adjustment for potential confounders, only...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Sep 1, 1995·Journal of the American Dietetic Association·P L BeyerW C Koller
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H S MarkusG M Stern
Sep 19, 2001·Mayo Clinic Proceedings·E P BourasJ S Scolapio
Nov 13, 2002·Neurology·L DjousséR H Myers
May 6, 2003·Annals of Neurology·Honglei ChenAlberto Ascherio
Aug 3, 2004·Acta Neurologica Scandinavica·B LorefältA-K Granérus
Mar 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Ergun Y UcWilliam J Evans
Mar 30, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Kate S M TaylorW Cairns S Smith
Aug 29, 2006·Parkinsonism & Related Disorders·Jagdish C SharmaIan Ross
Aug 22, 2007·American Journal of Epidemiology·Giancarlo LogroscinoI-Min Lee
Nov 22, 2007·Journal of the American Geriatrics Society·Anna Rita AttiLaura Fratiglioni
May 13, 2008·Journal of Clinical Epidemiology·K S M TaylorC E Counsell
Jul 19, 2011·Archives of Gerontology and Geriatrics·Hyun Jung KimAe Young Lee
Nov 22, 2011·Parkinsonism & Related Disorders·Marjolein A van der MarckMarten Munneke
Feb 7, 2012·International Journal of Palliative Nursing·Richard WalkerWilliam Gray
Jun 12, 2012·Parkinsonism & Related Disorders·Jagdish C Sharma, Janice Turton
Oct 16, 2013·Alzheimer Disease and Associated Disorders·Lilah M BesserDeborah R Gustafson
Oct 15, 2014·Neurodegenerative Disease Management·Jagdish C Sharma, Michael Vassallo
May 6, 2015·PloS One·Umer AkbarMichael S Okun
May 24, 2016·Parkinsonism & Related Disorders·Angus D MacleodCarl E Counsell
Jul 18, 2017·Journal of Neurology·Anne-Marie WillsUNKNOWN NINDS NET-PD Investigators

❮ Previous
Next ❯

Citations

May 19, 2019·Journal of Neural Transmission·Kyoungjune PakIn Joo Kim
Oct 20, 2018·Frontiers in Molecular Neuroscience·Elodie CuvelierKarim Belarbi
Oct 22, 2020·Future Microbiology·Federica Del ChiericoFabrizio Stocchi
Nov 18, 2020·The Journal of Clinical Hypertension·Ehud Grossman
Jan 20, 2021·Parkinsonism & Related Disorders·Shadi GhourchianLisa M Shulman
Feb 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Shengfang SongHonglei Chen
Apr 16, 2021·Current Alzheimer Research·Chao WangZuxun Lu

❮ Previous
Next ❯

Software Mentioned

Stata
Statistical Package for Social Sciences

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.