Easier said than done: ABO compatibility and D matching in apheresis platelet transfusions

Transfusion
Nancy M DunbarZbigniew M Szczepiorkowski

Abstract

Many hospital transfusion services prioritize ABO plasma compatibility in platelet (PLT) transfusion to minimize risk for acute hemolytic transfusion reactions. In spite of the low risk of D alloimmunization associated with apheresis PLT transfusion, attempts may also be made to provide D- PLTs to D- patients. This study was undertaken to assess how often ABO compatibility and/or D matching occurs at our institution and how the ABO and D mix of our PLT supply impacts PLT selection. We retrospectively reviewed the ABO and D type of all PLTs transfused plus the age, sex, and ABO and D type of all PLT recipients between January 2010 and March 2014 (51 months). We provided ABO-identical PLTs for 5281 (54.6%), ABO plasma-compatible and cellular-incompatible for 3136 (32.4%), ABO low-titer plasma-incompatible and cellular-compatible for 1150 (11.9%), ABO plasma-incompatible and cellular-compatible for 30 (0.3%), and ABO plasma-incompatible and cellular-incompatible for 72 (0.7%). PLT supply did not match PLT demand based on patient ABO type, primarily due to a lower than expected supply of group O PLTs and higher than expected supply of group A and AB. D- patients were less likely to receive ABO-identical PLT transfusions (p = 0.0008...Continue Reading

References

Mar 7, 1970·British Medical Journal·H H GunsonV I Rawlinson
Jul 18, 2008·Transfusion·Laura L CoolingRobertson D Davenport
Dec 26, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Cassandra D JosephsonChristopher D Hillyer
Aug 24, 2012·Current Opinion in Hematology·Nancy M DunbarLarry J Dumont
Aug 8, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Joan CidMark H Yazer
Feb 18, 2014·Transfusion·Arben AsllaniLawrence Ettkin
Mar 13, 2014·Transfusion·Michael Boo
Oct 7, 2014·British Journal of Haematology·Joan CidUNKNOWN Biomedical Excellence for Safer Transfusion collaborative

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Citations

Sep 22, 2015·Current Opinion in Hematology·Kyle Annen, Jordan E Olson
Dec 23, 2016·British Journal of Haematology·Lise J EstcourtUNKNOWN British Committee for Standards in Haematology
Jan 9, 2020·Transfusion·Natalie MalvikC Michael Knudson
Feb 23, 2020·Transfusion·Jefferson M JonesSridhar V Basavaraju
Oct 3, 2019·The New England Journal of Medicine·Sandhya R PanchHarvey G Klein
Jun 22, 2018·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Johanna ReckhausBehrouz Mansouri Taleghani
Oct 3, 2019·The New England Journal of Medicine·Tomohiko SatoTetsunori Tasaki
Dec 5, 2020·Hematology·Nancy M Dunbar
Jan 27, 2021·Clinics in Laboratory Medicine·Nataliya Sostin, Jeanne E Hendrickson
Jun 17, 2020·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P Moncharmont
Aug 20, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M LikerB G Ćepulić

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