East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome

Circulation
Yuji MizunoHirofumi Yasue

Abstract

Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese. The study subjects consisted of 202 patients in whom intracoronary injection of acetylcholine was performed by angiography on suspicion of CSA (119 men and 83 women; mean age, 66.2±11.4 years). They were divided into CSA (112 patients) and control groups (90 patients). ALDH2 genotyping was performed by the direct application of the TaqMan polymerase chain reaction system on dried whole blood. Clinical and laboratory data were examined using conventional methods. The frequencies of male sex, ALDH2*2 genotype carriers, alcohol flushing syndrome, tobacco smoking, and the plasma level of uric acid were higher (P<0.001, P<0.001, P<0.001, P<0.001, and P=0.007, respectively) and the plasma high-density lipoprotein cholesterol levels were lower (P<0.001) in the CSA group than in the control group. The multivariable logistic regression analysis revealed that ALDH2*2 genotype and smoking were significantly a...Continue Reading

References

Oct 1, 1988·Journal of the American College of Cardiology·K OkumuraK Matsuyama
Sep 30, 1999·The Tohoku Journal of Experimental Medicine·T SekiS Kasahara
Nov 28, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shuichi TakagiYoichi Goto
Jan 10, 2004·Antioxidants & Redox Signaling·Shinzo MiyamotoHisao Ogawa
Jun 3, 2004·European Heart Journal·Yosuke MuraseMitsuhiro Yokota
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhiqiang ChenJonathan S Stamler
Apr 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sangmee Ahn JoInho Jo
Jun 5, 2008·Journal of cardiology·Hirofumi YasueYuji Mizuno
Jul 2, 2008·Circulation·Kathryn L Lunetta
Sep 13, 2008·Science·Che-Hong ChenDaria Mochly-Rosen
Feb 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Takayuki OgawaMichihiro Yoshimura
May 22, 2009·Annals of Human Genetics·Hui LiKenneth K Kidd
Nov 21, 2009·Circulation Research·Bradford G Hill, Aruni Bhatnagar
Jun 19, 2010·International Heart Journal·Yoshinobu MorikawaHirofumi Yasue
Jul 31, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
May 20, 2011·Annals of Human Genetics·Hui LiKenneth K Kidd
Jun 15, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Munenori KosugiKyoichi Mizuno
Oct 1, 2011·Journal of Cellular and Molecular Medicine·Feng XuYun Zhang
Oct 6, 2011·European Journal of Human Genetics : EJHG·Fumihiko TakeuchiNorihiro Kato
Dec 1, 2012·Free Radical Biology & Medicine·Surendra SinghVasilis Vasiliou
Aug 7, 2013·Journal of the American College of Cardiology·Yusuke TakagiUNKNOWN Japanese Coronary Spasm Association
Jan 3, 2014·Physiological Reviews·Che-Hong ChenDaria Mochly-Rosen
Feb 28, 2014·Circulation·Scott Kinlay
Mar 13, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mariko HayashidaKenji Kinoshita
May 7, 2014·Alcoholism, Clinical and Experimental Research·Gaeun KangJong-Keun Kim

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Citations

Dec 3, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji MizunoHirofumi Yasue
Aug 4, 2016·Stroke; a Journal of Cerebral Circulation·Yueh-Feng SungGiia-Sheun Peng
Aug 2, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Miho ImaiKenji Kinoshita
Dec 22, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·John F BeltrameUNKNOWN Coronary Vasomotion Disorders International Study Group (COVADIS)
Feb 2, 2018·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Nov 8, 2019·Expert Opinion on Therapeutic Targets·Mitsuru KimuraSusumu Higuchi
Sep 17, 2020·International Journal of Molecular Sciences·Lung-An HsuGwo-Jyh Chang
Feb 13, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hirofumi YasueEisaku Harada
Feb 6, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji MizunoHirofumi Yasue
Feb 18, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Kyung-Duk Min, Masafumi Kitakaze
Jun 9, 2020·Journal of Interventional Cardiology·Anthony MattaJerome Roncalli
Oct 6, 2020·World Journal of Cardiology·Hiroki TeragawaYuichi Orita
Feb 13, 2018·Expert Opinion on Therapeutic Targets·Thomas Münzel, Andreas Daiber
Sep 19, 2018·Free Radical Biology & Medicine·Ligia Akemi KiyunaJulio Cesar Batista Ferreira
Oct 12, 2021·Expert Review of Cardiovascular Therapy·Thanh Ha NguyenJohn D Horowitz

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