Eastern equine encephalomyelitis virus infection in a horse from California

Emerging Infectious Diseases
Robert P FranklinMichael D Parker

Abstract

A yearling quarter horse, which was raised in southern California, received routine vaccinations for prevention of infection by Eastern equine encephalomyelitis virus (EEEV). One week later, severe neurologic signs developed, and the horse was humanely destroyed. A vaccine-related encephalomyelitis was later suspected. A final diagnosis of EEEV infection was established on the basis of acute onset of the neurologic signs, histopathologic and serologic testing, and isolation and molecular characterization of EEEV from brain tissue. The vaccine was extensively tested for viral inactivation. Nucleotide sequences from the vaccine and the virus isolated in the affected horse were also compared. In California, arboviral encephalomyelitides are rarely reported, and EEEV infection has not previously been documented. This report describes the occurrence of EEEV infection in the horse and the investigation to determine the source of infection, which was not definitively identified.

References

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May 25, 2001·Journal of Medical Entomology·W K ReisenV M Martinez

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Citations

Aug 8, 2014·PLoS Neglected Tropical Diseases·William J WeiseScott C Weaver
Nov 13, 2004·Biologicals : Journal of the International Association of Biological Standardization·Thierry BurnoufJosé-María Gutiérrez
Jul 26, 2015·Journal of Virological Methods·C H GoodmanB W Johnson
Mar 2, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kate E PennickMatti Kiupel
Oct 6, 2018·The Open Virology Journal·Balvinder KumarB N Tripathi
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Dec 2, 2020·Animals : an Open Access Journal From MDPI·Rebeca Jéssica Falcão CâmaraJenner Karlisson Pimenta Dos Reis

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Methods Mentioned

BETA
electron microscopy
enzyme-linked immunosorbent assay

Software Mentioned

BLAST

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