Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu2+ in Wilson's Disease

ACS Applied Materials & Interfaces
Yibing ShiFuyou Li

Abstract

Copper(II) is one of the essential metal elements in human body, which can accumulate in many organs and finally excrete in urine. Excessive load of Cu2+ can cause liver cirrhosis, kidney dysfunction, and many neurological symptoms in the case of Wilson's disease (WD). Therefore, the selective and efficient detection of Cu2+ is of great importance. Although various fluorescent probes have been reported for the detection of Cu2+, an efficient and capable probe is still rare for patients' self-use on a routine basis. In this study, we developed an easy-to-use probe CY1 based on UV-vis-near-infrared absorption changes with excellent sensitivity and selectivity for Cu2+. The mechanism of oxidation of CY1 by Cu2+ was first explored. We demonstrated the role of the probe in the quantitative detection of Cu2+ in urine from WD patients and showed that it has great potential for clinical applications.

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Citations

Apr 11, 2021·Biological Trace Element Research·Lyudmila V Bel'skayaVictor K Kosenok
Oct 15, 2020·Methods and Applications in Fluorescence·Sofia A ZakharenkovaMikhail K Beklemishev
Jul 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sheng ZhangHua Wang
Feb 27, 2020·ACS Applied Materials & Interfaces·Mei-Rong CuiHong-Yuan Chen
Aug 27, 2021·Mikrochimica Acta·Xiaowen OuShenshan Zhan

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