Eating "junk food" has opposite effects on intrinsic excitability of nucleus accumbens core neurons in obesity-susceptible versus -resistant rats

Journal of Neurophysiology
Max F Oginsky, Carrie R Ferrario

Abstract

The nucleus accumbens (NAc) plays critical roles in motivated behaviors, including food seeking and feeding. Differences in NAc function contribute to overeating that drives obesity, but the underlying mechanisms are poorly understood. In addition, there is a fair degree of variation in individual susceptibility versus resistance to obesity that is due in part to differences in NAc function. For example, using selectively bred obesity-prone and obesity-resistant rats, we have found that excitability of medium spiny neurons (MSNs) within the NAc core is enhanced in obesity-prone versus -resistant populations, before any diet manipulation. However, it is unknown whether consumption of sugary, fatty "junk food" alters MSN excitability. Here whole cell patch-clamp recordings were conducted to examine MSN intrinsic excitability in adult male obesity-prone and obesity-resistant rats with and without exposure to a sugary, fatty junk food diet. We replicated our initial finding that basal excitability is enhanced in obesity-prone versus obesity-resistant rats and determined that this is due to a lower fast transient potassium current (IA) in prone versus resistant groups. In addition, the junk food diet had opposite effects on excitabi...Continue Reading

References

Jun 28, 1992·Annals of the New York Academy of Sciences·D J Henry, F J White
Dec 1, 1989·Journal of Neurophysiology·N UchimuraR A North
Aug 1, 1997·The American Journal of Physiology·B E LevinR E Keesey
Jun 9, 2000·Annual Review of Neuroscience·S M NicolaR C Malenka
Nov 9, 2000·Journal of Neurophysiology·M L Belleau, R A Warren
Sep 21, 2004·IEEE Transactions on Bio-medical Engineering·Murat SekerliRobert J Butera
Mar 8, 2006·Nature Neuroscience·Yan DongRobert C Malenka
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tracy S GertlerD James Surmeier
Feb 27, 2009·Journal of Neurophysiology·Fernando Kasanetz, Olivier J Manzoni
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D M Small
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saïd Kourrich, Mark J Thomas
Mar 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ping MuYan Dong
Jul 27, 2010·Trends in Neurosciences·Marina E Wolf
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathryn E DemosWilliam M Kelley
Nov 24, 2012·Critical Reviews in Biochemistry and Molecular Biology·Dardo Tomasi, Nora D Volkow
Dec 25, 2012·Neuroscience and Biobehavioral Reviews·Uku VainikLesley K Fellows
Feb 9, 2013·American Journal of Physiology. Cell Physiology·Xin JinChun Jiang
Feb 24, 2015·Nature Reviews. Neuroscience·Saïd KourrichAntonello Bonci
Mar 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mike J F RobinsonCarrie R Ferrario
Jun 28, 2015·Neuroscience·L M YagerS M Ferguson
Jul 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cecile HryhorczukStephanie Fulton
Jul 8, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Max F OginskyCarrie R Ferrario
Dec 3, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie R Ferrario
Jan 2, 2018·Neuropharmacology·Rifka C Derman, Carrie R Ferrario

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Citations

Jul 31, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yanaira Alonso-CaraballoCarrie R Ferrario
Mar 10, 2021·Journal of Neuroendocrinology·Cait A Beddows, Garron T Dodd
May 18, 2020·Physiology & Behavior·P M DingessT E Brown
Apr 17, 2021·Neuropharmacology·Katherine M SerafineEric P Zorrilla
May 25, 2021·The European Journal of Neuroscience·Diana SketrieneRobyn M Brown
Jul 10, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shani GendelisYonatan M Kupchik

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GraphPad Prism

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