Ebola virus dynamics in mice treated with favipiravir

Antiviral Research
Vincent MadelainJérémie Guedj

Abstract

The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, such as the half-life of productively infected cells, of about 6h, and the basic reproductive number which indicates that virus produced by a single infected cell productively infects about 9 new cells. Furthermore, the model predicted that favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. The model could be particularly helpful to guide future studies evaluating favipiravir in larger animals.

References

Mar 16, 2000·Journal of Theoretical Biology·M A StaffordA S Perelson
Mar 22, 2002·Nature Reviews. Immunology·Alan S Perelson
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Yousuke FurutaKimiyasu Shiraki
Jul 15, 2006·Journal of Virology·Prasith BaccamAlan S Perelson
Jun 26, 2007·Nature Reviews. Immunology·Mansour MohamadzadehAlan L Schmaljohn
Nov 19, 2010·Lancet·Heinz Feldmann, Thomas W Geisbert
Jan 5, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Amber M Smith, Alan S Perelson
Mar 8, 2011·PLoS Computational Biology·Amber M SmithAlan S Perelson
Sep 20, 2011·Viruses·Judith OlejnikElke Mühlberger
Feb 14, 2013·Current Opinion in Virology·David SafronetzHeinz Feldmann
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jeremie GuedjAlan S Perelson
Jun 26, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Laetitia Canini, Alan S Perelson
Dec 2, 2014·The Lancet Infectious Diseases·France MentréDenis Malvy
Mar 6, 2015·JAMA : the Journal of the American Medical Association·Thomas W Geisbert
Jul 1, 2015·Nature Reviews. Gastroenterology & Hepatology·Alan S Perelson, Jeremie Guedj

❮ Previous
Next ❯

Citations

Sep 1, 2016·Annual Review of Virology·M L BoisenL M Branco
Oct 28, 2016·Antiviral Research·Alexey MartyushevShingo Iwami
Feb 24, 2017·PLoS Neglected Tropical Diseases·Thi Huyen Tram NguyenUNKNOWN JIKI study group
Nov 1, 2016·Antimicrobial Agents and Chemotherapy·Vincent MadelainHervé Raoul
Jun 15, 2016·Antimicrobial Agents and Chemotherapy·Xiangguo QiuMichel Chrétien
Mar 22, 2020·CPT: Pharmacometrics & Systems Pharmacology·Vincent MadelainJérémie Guedj
Jun 14, 2019·PLoS Pathogens·Traci L BrickerAdrianus C M Boon
Aug 22, 2018·Immunological Reviews·Katharine Best, Alan S Perelson
Jul 25, 2019·Bulletin of Mathematical Biology·Vladimir ReinharzDanny Barash
Sep 17, 2017·Scientific Reports·Paola Carrillo-BustamanteFrederik Graw
Nov 13, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Faryal KhamisIbrahim Al-Zakwani
Oct 30, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yan LouYunqing Qiu
Jan 26, 2021·Archives of Virology·Hany M DabbousMohamed Awad Tageldin
Nov 3, 2020·PLoS Computational Biology·Laura E LiaoCarmen Molina-París
Mar 20, 2018·Mathematical Biosciences·Vladimir ReinharzDanny Barash
Aug 11, 2021·Viruses·Olivier EscaffreJason E Comer
Aug 28, 2021·Signal Transduction and Targeted Therapy·Yu-Wen ZhouXue-Lei Ma
Dec 3, 2020·Current HIV Research·Melda TurkenSukran Kose

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.