Ebola virus vaccine: benefit and risks of adenovirus-based vectors

Expert Review of Vaccines
Franck Jd MennechetEric J Kremer

Abstract

In 2014, an outbreak of Ebola virus spread rapidly in West Africa. The epidemic killed more than 10,000 people and resulted in transmissions outside the endemic countries. WHO hopes for effective vaccines by the end of 2015. Numerous vaccine candidates have been proposed, and several are currently being evaluated in humans. Among the vaccine candidates are vectors derived from adenovirus (Ad). Despite previous encouraging preclinical and Phase I/II trials, Ad vectors used in three Phase II trials targeting HIV were prematurely interrupted because of the lack of demonstrated efficacy. The vaccine was not only ineffective but also led to a higher rate of HIV acquisition. In this context, the authors discuss the potential benefits, risks and impact of using Ad-derived vaccines to control Ebola virus disease.

References

Nov 12, 2005·Journal of Virology·Matthieu Perreau, Eric J Kremer
Oct 19, 2007·Journal of Virology·Ann M LeenCatherine M Bollard
Jan 25, 2008·Clinical and Vaccine Immunology : CVI·Dana L SwensonWilliam D Pratt
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Adel BenlahrechSteven Patterson
Feb 26, 2010·Clinical and Vaccine Immunology : CVI·William D PrattJohn Y Dong
Dec 29, 2011·The Journal of Clinical Investigation·Nicole FrahmM Juliana McElrath
Nov 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Daniel E ZakM Juliana McElrath
Oct 9, 2013·The New England Journal of Medicine·Scott M HammerUNKNOWN HVTN 505 Study Team
Dec 18, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Aurelie CubizolleEric J Kremer
Feb 15, 2014·The Journal of Infectious Diseases·Anita K McElroyChristina F Spiropoulou
Feb 25, 2014·The Lancet Infectious Diseases·Glenda E GrayUNKNOWN HVTN 503/Phambili study team
Mar 13, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicolas SerratriceEric J Kremer
Apr 5, 2014·Science·Anthony S FauciSusan P Buchbinder
Apr 26, 2014·Future Microbiology·Mária BenkőEric J Kremer
Aug 1, 2014·PLoS Neglected Tropical Diseases·Daniel G Bausch, Lara Schwarz
Sep 10, 2014·ELife·David M PigottSimon I Hay
Sep 13, 2014·Science·Peter Piot
Nov 13, 2014·The Journal of Infectious Diseases·Erin M KahleUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Mar 12, 2015·BMJ : British Medical Journal·Eric J Kremer, Philippe Van de Perre
Jun 4, 2015·Emerging Microbes & Infections·Xiang WangDongming Zhou
Jun 5, 2015·PLoS Pathogens·Eric J Kremer, Glen R Nemerow
Jun 28, 2015·The Lancet Infectious Diseases·Franco Pagnoni, Andrea Bosman

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Citations

Sep 17, 2016·PLoS Pathogens·Karsten EichholzEric J Kremer
May 28, 2019·Expert Review of Vaccines·Franck J D MennechetEric J Kremer
Apr 16, 2019·Frontiers in Molecular Neuroscience·Danila Del RioEric J Kremer
Feb 29, 2020·Scientific Reports·Brianna L BullardEric A Weaver
Oct 11, 2017·Médecine sciences : M/S·Franck J D MennechetEric J Kremer

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