Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis

Journal of Virology
Priya LuthraChristopher F Basler

Abstract

Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral polymerase cofactor. Previously, the 8-kDa cytoplasmic dynein light chain (LC8) was demonstrated to interact with VP35, but the functional consequences were unclear. Here we demonstrate that the interaction is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis. Mutational analysis demonstrates that VP35 interaction is required for the functional effects of LC8.

References

Aug 15, 1997·The Journal of Biological Chemistry·S E BenashskiS M King
Oct 29, 1998·Virology·S BeckerE Mühlberger
Aug 31, 2000·Nature Structural Biology·N TarbouriechW P Burmeister
Oct 12, 2000·Journal of Virology·H RauxD Blondel
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C F BaslerP Palese
Jan 20, 2001·The Journal of Biological Chemistry·K W LoM Zhang
Jun 28, 2003·Journal of Virology·Christopher F BaslerAdolfo García-Sastre
Aug 9, 2003·The Journal of Biological Chemistry·Wenning WangMingjie Zhang
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gene S TanMatthias J Schnell
Jan 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Daisy W LeungGaya K Amarasinghe
May 1, 2009·Journal of Virology·Toru KubotaKeiko Ozato
Dec 21, 2010·Cellular Microbiology·Marc A SchneiderCarsten Lambert
Dec 24, 2010·Virulence·Daisy W LeungGaya K Amarasinghe
Jul 23, 2011·The FEBS Journal·Javier Merino-GraciaIgnacio Rodríguez-Crespo

❮ Previous
Next ❯

Citations

May 6, 2016·Annual Review of Genomics and Human Genetics·Angela L Rasmussen
Sep 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ji-Xia RenYong Xie
May 4, 2018·PLoS Neglected Tropical Diseases·Diego Cantoni, Jeremy S Rossman
Nov 17, 2016·Journal of Virology·Jessica F BruhnErica Ollmann Saphire
Jun 10, 2016·Journal of Virology·Nadine BiedenkopfRoland K Hartmann
Aug 4, 2019·Journal of Virology·Yuqin ZhouDzwokai Ma
May 9, 2019·Nucleic Acids Research·Ting ShuXi Zhou
Nov 7, 2019·Biochemical and Biophysical Research Communications·Lin ZhuCheng Cao
Feb 26, 2021·The Journal of Microbiology·Dahwan LimBonsu Ku
Apr 20, 2019·Current Opinion in Virology·Megan R Edwards, Christopher F Basler
Dec 29, 2018·Biochemistry·Chamnongsak Ken ChanthamontriDaisy W Leung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Infectious Diseases
Reed S ShabmanChristopher F Basler
BMJ : British Medical Journal
D Bennett, D Brown
Relevé épidémiologique Hebdomadaire
Pediatric Annals
Stanford T Shulman
© 2022 Meta ULC. All rights reserved