Ebselen ameliorates β-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic Alzheimer's disease mice

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Yongli XieQiong Liu

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease which is clinically characterized by memory loss and cognitive decline caused by protein misfolding and aggregation. Imbalance between free radicals and the antioxidant system is a prominent and early feature in the neuropathology of AD. Selenium (Se), a vital trace element with excellent antioxidant potential, is preferentially retained in the brain in Se-limited conditions and has been reported to provide neuroprotection through resisting oxidative damage. In this paper, we studied for the first time the potential of Ebselen, a lipid-soluble selenium compound with GPx-like activity, in the treatment of cognitive dysfunction and neuropathology of triple-transgenic AD (3 × Tg-AD) mice, AD model cell, and primary culture. We demonstrated that Ebselen inhibited oxidative stress in both AD model cells and mouse brains with increasing GPx and SOD activities and meanwhile reduced p38 mitogen-activated protein kinases activities. By decreasing the expression of amyloid precursor protein and β-secretase, Ebselen reduced the levels of Aβ in AD neurons and mouse brains, especially the most toxic oligomeric form. Besides, mislocation of phosphorylated tau in neurons and ...Continue Reading

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Aug 30, 2000·Lancet·M P Rayman
Nov 18, 2000·Journal of Neuropathology and Experimental Neurology·X ZhuM A Smith
Mar 13, 2001·Cerebrovascular Diseases·E Martínez-Vila, P I Sieira
Aug 2, 2001·Journal of Biochemistry·K Nakajima, S Kohsaka
Feb 5, 2003·Neuro-Signals·Xiongwei ZhuMark A Smith
Oct 14, 2003·Experimental Neurology·Anyang SunGuoying Bing
Apr 24, 2004·Annals of the New York Academy of Sciences·Xudong HuangJack T Rogers
Jun 9, 2004·Protein and Peptide Letters·Dominic M Walsh, Dennis J Selkoe
Aug 6, 2004·Nature·Mark P Mattson
Aug 7, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Koso EgiStephen M Wildhirt
Mar 23, 2005·Brain Research·Fernanda Bossemeyer CenturiãoJoão Batista Teixeira Rocha
May 5, 2006·Journal of Neuroscience Research·Qitao RanArlan Richardson
Aug 26, 2006·The European Journal of Neuroscience·Martin CenteMichal Novak
Nov 4, 2006·Science·Michel Goedert, Maria Grazia Spillantini
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Dec 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xinglong WangXiongwei Zhu
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniela PuzzoOttavio Arancio
Oct 27, 2009·Biochemical and Biophysical Research Communications·Ha-Na WooDong-Gyu Jo
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Janet van EerselLars M Ittner
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaomin LiDennis J Selkoe
May 20, 2011·Journal of Alzheimer's Disease : JAD·Martin LoefHarald Walach
Jan 31, 2012·Nature Neuroscience·Iryna BenilovaBart De Strooper
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Eva-Maria Mandelkow, Eckhard Mandelkow
Oct 6, 2012·Current Alzheimer Research·Senthilkumar SivanesanJayakumar Rajadas
Sep 10, 2013·Neurochemical Research·Gabriela Lorea GodoiHiram Larangeira de Almeida
Apr 3, 2015·Molecular Neurobiology·Zi-Xuan WangJin-Tai Yu

❮ Previous
Next ❯

Citations

Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong Kil Lee, Nam-Jung Kim
Nov 22, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Jun 4, 2020·Antioxidants & Redox Signaling·Germán Plascencia-Villa, George Perry
Feb 18, 2020·Frontiers in Molecular Neuroscience·Michelle Flores DominguesCelia Regina Carlini
Mar 11, 2020·Frontiers in Pharmacology·Decheng BiXu Xu
Feb 26, 2020·Molecular Biology Reports·Isabella Pregardier KlannCristina Wayne Nogueira
Nov 24, 2020·Future Medicinal Chemistry·Jun WangLili Zou
Nov 22, 2020·The Journal of Biological Chemistry·Peng LeiAshley I Bush
Aug 30, 2019·IBRO Reports·Sumit BaruaJong Eun Lee
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Garima SharmaHyoung-Chun Kim
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha
Jun 7, 2021·Trends in Pharmacological Sciences·Karolin RoemhildTwan Lammers
Jul 4, 2021·European Journal of Medicinal Chemistry·Hongyan ChuaiMinhang Xin
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio SantiLuca Sancineto
Oct 23, 2019·Journal of Medicinal Chemistry·Ana Carolina RuberteDaniel Plano

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
flow cytometry
protein assay
MDA

Software Mentioned

Watermaze MT - 200
Quantity One

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.