Ebselen has lithium-like effects on central 5-HT2A receptor function

British Journal of Pharmacology
I AntoniadouT Sharp

Abstract

Lithium's antidepressant action may be mediated by inhibition of inositol monophosphatase (IMPase), a key enzyme in Gq -protein coupled receptor signalling. Recently, the antioxidant agent ebselen was identified as an IMPase inhibitor. Here, we investigated both ebselen and lithium in models of the 5-HT2A receptor, a Gq -protein coupled receptor involved in lithium's actions. 5-HT2A receptor function was assessed in mice by measuring the behavioural (head-twitches, ear scratches) and molecular (cortical immediate early gene [IEG] mRNA; Arc, c-fos, Egr2) responses to 5-HT2A receptor agonists. Ebselen and lithium were administered either acutely or repeatedly prior to assessment of 5-HT2A receptor function. Because lithium and 5-HT2A receptor antagonists augment the action of selective serotonin reuptake inhibitors (SSRIs), ebselen was tested for this activity by co-administration with the SSRI citalopram in microdialysis (extracellular 5-HT) experiments. Acute and repeated administration of ebselen inhibited behavioural and IEG responses to the 5-HT2A receptor agonist DOI. Repeated lithium also inhibited DOI-evoked behavioural and IEG responses. In comparison, a selective IMPase inhibitor (L-690330) attenuated the behavioural re...Continue Reading

References

Oct 27, 1971·Nature: New Biology·J H Allison, M A Stewart
Dec 13, 1993·Neuroreport·R A LeslieD G Grahame-Smith
Mar 1, 1997·Medicinal Research Reviews·J R Atack
Feb 22, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P DavanzoJ McCracken
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Richard A RabinJ C Winter
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Deborah M Kurrasch-OrbaughDavid E Nichols
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerard J MarekLawrence H Price
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas I F H CremersLaurence H Tecott
Aug 19, 2004·The International Journal of Neuropsychopharmacology·Todd D GouldHusseini K Manji
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd D Gould, Husseini K Manji
Feb 20, 2007·Mini Reviews in Medicinal Chemistry·D J Miller, R K Allemann
Apr 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kim CrynsDieder Moechars
Nov 13, 2007·Trends in Pharmacological Sciences·Trevor SharpPhilip Quérée
Feb 26, 2008·Nature·Javier González-MaesoStuart C Sealfon
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Jan 7, 2011·The International Journal of Neuropsychopharmacology·Mikhail Kalinichev, Lee A Dawson
May 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Konstantinos N FountoulakisEduard Vieta
Aug 25, 2012·Expert Opinion on Investigational Drugs·Gaël QuesseveurBruno P Guiard
Jan 10, 2013·Nature Communications·Nisha SinghGrant C Churchill
May 15, 2013·Lancet·John R Geddes, David J Miklowitz
Jul 19, 2014·Behavioural Brain Research·Adam L Halberstadt
Jan 21, 2015·Pharmacology & Therapeutics·John D McCorvy, Bryan L Roth
May 13, 2015·British Journal of Pharmacology·John C McGrath, Elliot Lilley

❮ Previous
Next ❯

Citations

Jul 11, 2018·Journal of Psychopharmacology·Chris BarkusTrevor Sharp
Apr 19, 2019·Translational Psychiatry·João LimaStephen B McHugh
Nov 24, 2020·Future Medicinal Chemistry·Jun WangLili Zou
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio SantiLuca Sancineto
Jun 12, 2020·Neuropharmacology·Trevor Sharp, Nicholas M Barnes
Oct 23, 2019·Journal of Medicinal Chemistry·Ana Carolina RuberteDaniel Plano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved