EBV Associated Breast Cancer Whole Methylome Analysis Reveals Viral and Developmental Enriched Pathways

Frontiers in Oncology
Mohammad O E AbdallahHiba S Mohamed

Abstract

Background: Breast cancer (BC) ranks among the most common cancers in Sudan and worldwide with hefty toll on female health and human resources. Recent studies have uncovered a common BC signature characterized by low frequency of oncogenic mutations and high frequency of epigenetic silencing of major BC tumor suppressor genes. Therefore, we conducted a pilot genome-wide methylome study to characterize aberrant DNA methylation in breast cancer. Results: Differential methylation analysis between primary tumor samples and normal samples from healthy adjacent tissues yielded 20,188 differentially methylated positions (DMPs), which is further divided into 13,633 hypermethylated sites corresponding to 5339 genes and 6,555 hypomethylated sites corresponding to 2811 genes. Moreover, bioinformatics analysis revealed epigenetic dysregulation of major developmental pathways including hippo signaling pathway. We also uncovered many clues to a possible role for EBV infection in BC. Conclusion: Our results clearly show the utility of epigenetic assays in interrogating breast cancer tumorigenesis, and pinpointing specific developmental and viral pathways dysregulation that might serve as potential biomarkers or targets for therapeutic interve...Continue Reading

References

Mar 9, 2002·Breast Cancer Research and Treatment·M A MasriM E Ibrahim
Sep 20, 2005·Genome Research·Belinda GiardineAnton Nekrutenko
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·H BermanT D Tlsty
Mar 3, 2009·Breast Cancer Research : BCR·Stella TommasiGerd P Pfeifer
Jul 21, 2009·International Journal of Cancer. Journal International Du Cancer·Weizhu ZhuEdward R Sauter
Jan 14, 2010·Current Protocols in Molecular Biology·Daniel BlankenbergJames Taylor
May 4, 2010·Nature Biotechnology·Cory Y McLeanGill Bejerano
Oct 6, 2010·Breast Cancer Research : BCR·Naiara G BediagaMarian M de Pancorbo
Nov 13, 2010·International Journal of Women's Health·Elgaili M ElgailiSulma I Mohammed
Nov 1, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·So Yeon ParkGyeong Hoon Kang
Oct 1, 2009·Epigenomics·Christoph Bock
Dec 1, 2011·Epigenomics·Sarah DedeurwaerderFrançois Fuks
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christos PolytarchouKevin Struhl
Aug 29, 2012·The Journal of Molecular Diagnostics : JMD·Diego M MarzeseMaría Roqué
Sep 1, 2012·Frontiers in Genetics·Frank Wessely, Richard D Emes
Dec 15, 2012·The Journal of Biological Chemistry·Joon-Ho ChoGoberdhan P Dimri
Jul 23, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Vladimir A NaumovVadim M Govorun
Jan 23, 2014·Nutrition and Cancer·Wenyi QinEdward R Sauter
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Maria E GonzalezCelina G Kleer
Mar 13, 2014·Infectious Agents and Cancer·Zeinab A YahiaMuntaser E Ibrahim
May 14, 2014·Cancer Medicine·Intisar E SaeedSulma I Mohammed
Jun 24, 2014·Nature Genetics·De-Chen LinH Phillip Koeffler
Jul 25, 2014·Annals of Medicine·Tiffany A KatzRachel C Jankowitz
Aug 2, 2014·PloS One·Marsha ReyngoldTimothy A Chan
Nov 16, 2014·Nucleic Acids Research·Wei-Yun HuangHsien-Da Huang
Nov 18, 2014·Frontiers in Genetics·Hans H NillerJanos Minarovits
Dec 4, 2014·Acta Biochimica Et Biophysica Sinica·Peiguo ShiCeshi Chen
Dec 4, 2014·Molecular Oncology·Olafur A StefanssonManel Esteller

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Citations

Feb 14, 2020·Current Clinical Microbiology Reports·Allaura S ConeDavid G Meckes
Oct 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yingfen WuWei Xiong
Apr 18, 2021·Human Molecular Genetics·Muntaser E Ibrahim
Dec 7, 2021·Frontiers in Immunology·Andrea AranMercè Martí

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Software Mentioned

Limma
compare
Nimble
Matalab
MSig perturbations
Nimbl
Cytoscape
R limma
ReactomeFI
RODAMAP

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