EBV-Associated Cancer and Autoimmunity: Searching for Therapies

Vaccines
Giovanni CaponeDarja Kanduc

Abstract

Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence. However, currently no effective anti-EBV immunotherapy is available. Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host. We report on a set of unique EBV EBNA1 peptides that might be used in designing peptide-based therapies able to specifically hitting the virus or neutralizing pathogenic autoantibodies.

References

Jan 1, 1991·Annual Review of Immunology·J B Rothbard, M L Gefter
Jan 1, 1984·Annual Review of Immunology·D C BenjaminE M Prager
Feb 11, 1983·Science·J G SutcliffeR A Lerner
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H L NimanR A Lerner
Jul 1, 1984·The Journal of Investigative Dermatology·T M ShinnickR A Lerner
Feb 1, 1994·Journal of Autoimmunity·E RivkinR G Lahita
Dec 6, 1996·The Journal of Biological Chemistry·T MacalmaM C Beckerle
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J LevitskayaM G Masucci
Jan 27, 1999·Arthritis and Rheumatism·K M UramotoS E Gabriel
Sep 11, 2002·European Journal of Immunology·Derek B Sant'AngeloLisa K Denzin
Jan 10, 2003·Nucleic Acids Research·Cathy H WuWinona C Barker
Aug 9, 2003·Blood·Agnieszka P SzremskaVeronika Sexl
Dec 14, 2004·Journal of Translational Medicine·Alberta LuccheseAnimesh A Sinha
Jun 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Valerie K SalatoMong-Shang Lin
Mar 15, 2006·Mayo Clinic Proceedings·Stephen M Ansell, James O Armitage
Aug 24, 2006·Journal of Translational Medicine·Alberta LuccheseDarja Kanduc
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graham S TaylorAlan B Rickinson
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Corey SmithRajiv Khanna
Oct 26, 2006·Journal of Translational Medicine·Giovanni AngeliniDarja Kanduc
Jul 13, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Eric Toussirot, Jean Roudier

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Citations

Jan 24, 2017·Immunologic Research·Yahel SegalYehuda Shoenfeld
Jul 1, 2015·Current Opinion in Rheumatology·Gillian C GoobieAnn E Clarke
Jan 15, 2020·Lupus·H A NoureldineI Uthman
May 8, 2018·Molecular and Clinical Oncology·Noriyuki HoriguchiNaoki Ohmiya
Sep 18, 2020·Global Medical Genetics·Darja Kanduc, Yehuda Shoenfeld
Nov 15, 2019·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katerina ZachovaMilan Raska
Jul 1, 2021·Hematology/oncology Clinics of North America·Harish N Vasudevan, Sue S Yom

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Datasets Mentioned

BETA
AY961628.3

Software Mentioned

ClustalW

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