EBV infection of T cells: potential role in malignant transformation

Seminars in Cancer Biology
C A KelleherE W Gelfand

Abstract

The presence of Epstein-Barr virus in different T-cell malignancies is now widely reported. In an effort to ascertain whether T cells are susceptible to EBV infection, we and others have detected the EBV receptor, CD21 on a population of immature thymocytes. We showed that EBV is a cofactor in stimulating proliferation of thymocytes. This proliferation may be a relevant factor in EBV-associated T-cell malignancies as well as EBV causation of acute infectious mononucleosis (AIM). We have further identified a subset of thymocytes that is infectable by EBV in which the genome remains linear in the first weeks after infection. We documented the transcription of the switch protein ZEBRA, an alternatively spliced form, RAZ, and EBNA-1 transcription from the Fp promoter. We hypothesise that EBV may be a cofactor in oncogenesis in T cells through several different pathways.

Citations

Feb 13, 2001·British Journal of Haematology·S HauptmannF Buttgereit
Aug 8, 2001·International Journal of Experimental Pathology·G NiedobitekH J Delecluse
May 25, 2007·Neuro-oncology·Brian Patrick O'NeillCaterina Giannini
Nov 26, 2016·Biomolecules·Shatadru Ghosh RoyAbhik Saha
Jan 23, 2002·Japanese Journal of Cancer Research : Gann·Izuru MaekawaShigeo Mori

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.