Abstract
The presence of Epstein-Barr virus in different T-cell malignancies is now widely reported. In an effort to ascertain whether T cells are susceptible to EBV infection, we and others have detected the EBV receptor, CD21 on a population of immature thymocytes. We showed that EBV is a cofactor in stimulating proliferation of thymocytes. This proliferation may be a relevant factor in EBV-associated T-cell malignancies as well as EBV causation of acute infectious mononucleosis (AIM). We have further identified a subset of thymocytes that is infectable by EBV in which the genome remains linear in the first weeks after infection. We documented the transcription of the switch protein ZEBRA, an alternatively spliced form, RAZ, and EBNA-1 transcription from the Fp promoter. We hypothesise that EBV may be a cofactor in oncogenesis in T cells through several different pathways.
Citations
Jun 16, 2011·Amino Acids·Mauricio UrquizaManuel E Patarroyo
Feb 13, 2001·British Journal of Haematology·S HauptmannF Buttgereit
Aug 8, 2001·International Journal of Experimental Pathology·G NiedobitekH J Delecluse
Mar 7, 2009·Blood·Julien Giron-MichelCaroline Besson
May 25, 2007·Neuro-oncology·Brian Patrick O'NeillCaterina Giannini
May 27, 2011·International Journal of Biological Sciences·Jiang LiYi-xin Zeng
May 3, 2000·Clinical and Experimental Immunology·C S VerbekeH Zentgraf
Dec 20, 2014·Mediators of Inflammation·Laurissa OuaguiaNadira Delhem
Sep 5, 2015·Virology Journal·Lingling SunBing Luo
Nov 26, 2016·Biomolecules·Shatadru Ghosh RoyAbhik Saha
Mar 1, 2002·Molecular Carcinogenesis·Manfred HergenhahnFrank Rösl
Mar 24, 1999·Journal of Medical Virology·E DrouetG Delsol
Sep 3, 2010·Cancer Immunology, Immunotherapy : CII·Mathilde BerthoméHenri Vié
Jan 23, 2002·Japanese Journal of Cancer Research : Gann·Izuru MaekawaShigeo Mori
Jun 15, 2017·Journal of Immunology Research·David H Dreyfus