Abstract
Epstein-Barr virus (EBV) usually infects epithelial cells in the oropharynx and B lymphocytes asymptomatically. Occasionally, however, EBV infects T-cells and natural killer (NK) cells, and infection of these cells has been associated with the development of leukemias and lymphomas. EBV-positive lymphoproliferative disorders of NK cells have been reported with increasing frequency, but the interactions between EBV and NK cells are not fully understood, in part because NK cells are not usually infected with EBV in vitro. The lymphoma-derived EBV-positive NK cell line, YT, has been useful in the study of EBV infection of NK cells. YT cells express the EBV-associated nuclear antigen (EBNA)-1, the latent membrane protein (LMP)-1, and LMP-2A, but not EBNA-2 and LMP-2B genes. This pattern of latent gene expression is compatible with a type II latency program, normally associated with nasopharyngeal carcinoma, Hodgkin's disease, and T-cell lymphoma. In this report, we summarize recent information on EBV-NK cell interactions and EBV-positive lymphoproliferative disorders of NK cells.
References
Dec 1, 1990·Circulation·M E Rosenthal, M E Josephson
Jul 1, 1989·The Journal of Clinical Investigation·K Kawa-HaK Hirai
Jul 1, 1995·British Journal of Haematology·S ShimodairaK Kitano
Mar 1, 1995·Baillière's Clinical Haematology·G TosatoC Sgadari
Dec 1, 1994·European Journal of Pediatrics·Y FukunagaM Yamamoto
Jan 5, 1995·The New England Journal of Medicine·K L McClainS B Murphy
Jan 5, 1995·The New England Journal of Medicine·E S LeeP S Dickman
Jun 17, 1994·Cell·G Klein
Apr 28, 1994·The New England Journal of Medicine·E B PapadopoulosT N Small
Jan 1, 1996·The American Journal of Surgical Pathology·E S JaffeF C Ho
Oct 1, 1995·British Journal of Haematology·T KanekoK Oshimi
Jun 1, 1996·International Journal of Hematology·K Oshimi
Oct 1, 1996·British Journal of Haematology·H KaneganeG Tosato
Nov 4, 1996·International Journal of Cancer. Journal International Du Cancer·A K ChiangF C Ho
Jan 6, 1997·International Journal of Cancer. Journal International Du Cancer·Y TomitaK Aozasa
Citations
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·A MaedaG Klein
Sep 6, 2003·The Journal of Surgical Research·Changguo ChenD Ranjan
Oct 9, 2002·Vox Sanguinis·S E GuberW R Mayr
Aug 31, 2002·Journal of Hematotherapy & Stem Cell Research·Jürgen LuhmChristoph Frohn
Oct 3, 1999·Current Opinion in Oncology·E Cesarman, E A Mesri
Jan 23, 1999·Current Opinion in Hematology·D E Mosier
Oct 9, 2002·Journal of Virology·Pascal TrempatPierre Brousset
Mar 4, 2005·American Journal of Clinical Pathology·Huiqing WuGeraldine S Pinkus
Oct 16, 2009·Journal of Medical Case Reports·Sotiris Plastiras, Ourania Kampessi
Dec 29, 2004·Leukemia & Lymphoma·Vinod A PullarkatRussell K Brynes
Jun 1, 2000·Leukemia & Lymphoma·P KanavarosP Gaulard
Jan 9, 2004·Clinics in Laboratory Medicine·Travis Henry, Stefano Tarantolo
Dec 29, 2004·Leukemia & Lymphoma·Anna RuskovaGeorge Chan
Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Kei-ji SugimotoKazuo Oshimi
Oct 26, 2001·Japanese Journal of Cancer Research : Gann·S SakajiriK Oshimi
Jan 23, 2002·Japanese Journal of Cancer Research : Gann·Izuru MaekawaShigeo Mori
May 10, 2000·Leukemia·H G Drexler, Y Matsuo
Sep 17, 2019·Cancer·Ilona ArgirionLaura S Rozek
Apr 25, 2002·The Journal of Biological Chemistry·Melanie TardifJean Gosselin
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zsuzsanna S NagyRobert A Kirken
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie TabiascoJean-Jacques Fournié
Jun 13, 2014·Molecular Medicine Reports·Yunlian TangRunliang Gan
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew P Thompson, Razelle Kurzrock
Feb 3, 2000·Archives of Pathology & Laboratory Medicine·J TaoA Fuchs
Jul 16, 2021·Expert Review of Hematology·Yumeng ZhangLubomir Sokol