EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment

Frontiers in Oncology
Hiroshi Kimura, Yok-Lam Kwong

Abstract

The quantification of circulating Epstein Barr virus (EBV) DNA loads has played an important role in the diagnosis and management of EBV-associated lymphoid malignancies. Viral load measurement is particularly useful for monitoring EBV-DNA in hematopoietic stem cell transplant patients, and for assessing the prognosis or response to therapy of EBV-associated intractable lymphomas like extranodal NK/T-cell lymphoma, nasal type. Cell-free EBV-DNA in plasma can be used as a biomarker for estimating the severity or prognosis of these lymphomas. In addition to plasma, whole blood has been used for the management of transplant patients. Although measuring EBV-DNA has been useful, there is a lack of standardization and the optimal specimens for measuring viral loads are unknown. This can be attributed to the different forms of EBV-DNA that exist in peripheral blood and the different pathologies that result from diverse EBV disease states. As a result, guidelines for EBV diagnosis or the initiation of treatment are unclear. However, the newly established World Health Organization standard for EBV quantification will encourage collaborative studies across institutions and countries to establish proper guidelines for EBV diagnosis and th...Continue Reading

Citations

Sep 6, 2019·Expert Review of Hematology·Eric TseYok-Lam Kwong
Oct 21, 2019·Immunology and Cell Biology·Clara LawlerPhilip G Stevenson
Jul 29, 2020·Blood Research·Seong Hyun Jeong
Apr 25, 2020·Case Reports in Hematology·Anthony J Febres-AldanaVathany Sriganeshan
Jun 21, 2019·Cells·Fabio Seiti Yamada YoshikawaLuanda Mara da Silva Oliveira
Aug 20, 2020·The Journal of Experimental Medicine·Benjamin FournierSylvain Latour
Aug 11, 2021·Viruses·Yessica Sánchez-Ponce, Ezequiel M Fuentes-Pananá
Dec 2, 2021·Journal of Medical Virology·Zhuo LiYang Han

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Methods Mentioned

BETA
biopsy
PCR

Related Concepts

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Blood And Marrow Transplantation

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