Eccentric contraction: unraveling mechanisms of force enhancement and energy conservation

The Journal of Experimental Biology
Kiisa C Nishikawa

Abstract

During the past century, physiologists have made steady progress in elucidating the molecular mechanisms of muscle contraction. However, this progress has so far failed to definitively explain the high force and low energy cost of eccentric muscle contraction. Hypotheses that have been proposed to explain increased muscle force during active stretch include cross-bridge mechanisms, sarcomere and half-sarcomere length non-uniformity, and engagement of a structural element upon muscle activation. The available evidence suggests that force enhancement results from an interaction between an elastic element in muscle sarcomeres, which is engaged upon activation, and the cross-bridges, which interact with the elastic elements to regulate their length and stiffness. Similarities between titin-based residual force enhancement in vertebrate muscle and twitchin-based 'catch' in invertebrate muscle suggest evolutionary homology. The winding filament hypothesis suggests plausible molecular mechanisms for effects of both Ca(2+) influx and cross-bridge cycling on titin in active muscle. This hypothesis proposes that the N2A region of titin binds to actin upon Ca(2+) influx, and that the PEVK region of titin winds on the thin filaments during...Continue Reading

References

Aug 22, 1977·Journal of Theoretical Biology·R S Morgan
Aug 1, 1976·Journal of Biochemistry·K Maruyama
Sep 4, 1992·Biochimica Et Biophysica Acta·Y TanakaS Ishiwata
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K WangR Ramirez-Mitchell
Jan 1, 1990·Electron Microscopy Reviews·M A GoldsteinR L Sass
Nov 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D M Wilson, J L Larimer
Feb 1, 1981·The Journal of Physiology·L E FordR M Simmons
Nov 1, 1982·The Journal of General Physiology·K A EdmanM I Noble
Feb 19, 1996·FEBS Letters·M S Kellermayer, H L Granzier
Jan 1, 1996·The Journal of Physiology·K A Edman, T Tsuchiya
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·I SaseK Kinosita
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·W A LinkeB Kolmerer
Feb 27, 1999·Current Opinion in Cell Biology·C C GregorioS Labeit
Dec 10, 1999·Biophysical Journal·J BordasP Boesecke
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·W SteffenJ Sleep
May 15, 2002·Nature Structural Biology·M Yusuf AliShin'ichi Ishiwata
May 23, 2002·Biophysical Journal·Maria A BagniFrancesco Colomo
Jun 6, 2003·Journal of Muscle Research and Cell Motility·Belinda BullardKevin Leonard
Nov 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dietmar LabeitHenk Granzier
Jan 30, 2004·American Journal of Physiology. Cell Physiology·M A BagniG Cecchi
Feb 21, 2004·Circulation Research·Henk L Granzier, Siegfried Labeit
Jul 28, 2004·Journal of Biomechanics·Dilson E Rassier, Walter Herzog
Dec 15, 2004·Biophysical Journal·Andrey K TsaturyanSergey Y Bershitsky
Aug 3, 2005·Trends in Cell Biology·Irina Agarkova, Jean-Claude Perriard
Dec 7, 2007·The Journal of Experimental Biology·Daisuke FunabaraShugo Watabe
Dec 27, 2007·Molecular Cell·Yujie SunYale E Goldman
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eleonore von CastelmurOlga Mayans
Mar 1, 2008·Journal of Applied Biomechanics·Walter HerzogAshi Mehta
Mar 20, 2008·Proceedings. Biological Sciences·V JoumaaW Herzog
Mar 25, 2009·Journal of Theoretical Biology·Christian RodeReinhard Blickhan
Apr 8, 2009·Journal of Theoretical Biology·Urs StoeckerJachen Denoth

❮ Previous
Next ❯

Citations

Nov 5, 2016·Annual Review of Physiology·Stan Lindstedt, Kiisa Nishikawa
Mar 11, 2017·Frontiers in Physiology·Michael O Harris-LoveBrian M Hoover
Sep 25, 2017·The Journal of Experimental Biology·Anthony L Hessel, Kiisa C Nishikawa
Jan 23, 2016·The Journal of Experimental Biology·Stan L Lindstedt
Jun 7, 2018·Integrative and Comparative Biology·N C Holt, C D Williams
Apr 3, 2019·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Natalie C Holt
May 10, 2019·Journal of Applied Physiology·Martin Lakie, Kenneth S Campbell
Jul 11, 2019·Journal of Muscle Research and Cell Motility·Kiisa NishikawaJenna A Monroy
Dec 22, 2019·The Journal of Experimental Biology·Uzma TahirKiisa C Nishikawa
Apr 16, 2020·Physiology·Kiisa Nishikawa
Apr 23, 2017·European Journal of Applied Physiology·Andrea LeeTejin Yoon
Mar 27, 2018·NMR in Biomedicine·Fabian NiessMartin Meyerspeer
Jul 14, 2018·European Journal of Applied Physiology·Christopher M MyersJohn P Florian
Aug 24, 2018·Integrative and Comparative Biology·C D Williams, N C Holt
Feb 25, 2017·Frontiers in Physiology·Anthony L HesselKiisa C Nishikawa
Jun 21, 2020·The Journal of Experimental Biology·Jackey ChenGeoffrey A Power
Dec 12, 2019·The Journal of Experimental Biology·Thomas LibbySimon Sponberg
Nov 7, 2019·International Journal of Molecular Sciences·Atsuki Fukutani, Walter Herzog
Jun 5, 2020·International Journal of Molecular Sciences·Kiisa NishikawaDhruv Mishra
Apr 5, 2018·Frontiers in Neuroscience·Yury Ivanenko, Victor S Gurfinkel
Oct 9, 2020·The American Journal of Sports Medicine·Brady GreenTania Pizzari
Jun 14, 2018·Frontiers in Robotics and AI·Khoi D NguyenMadhusudhan Venkadesan
Aug 12, 2021·Integrative Organismal Biology·P J BishopJ R Hutchinson
Oct 5, 2021·The Journal of Experimental Biology·Kiisa Nishikawa, Thomas G Huck
Jan 23, 2021·The Journal of Sports Medicine and Physical Fitness·William A FountainScott A Mazzetti
Nov 30, 2021·Journal of Functional Morphology and Kinesiology·Michael O Harris-LoveJustin W L Keogh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings. Biological Sciences
Kiisa C NishikawaStan L Lindstedt
Clinics
Fábio Carderelli Minozzo, Claudio Andre Barbosa de Lira
Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology
Dilson E Rassier, Walter Herzog
Journal of Applied Physiology
Dilson E Rassier, Walter Herzog
The Journal of Experimental Biology
Walter Herzog
© 2022 Meta ULC. All rights reserved