Eccentric exercise alters muscle sensory motor control through the release of inflammatory mediators

Brain Research
Tanguy MarquesteYves Jammes

Abstract

Following downhill exercise, muscle damage and local inflammatory reactions, induced by lengthening contractions, are observed and voluntary muscle activation decreases. The hypothesis that feedback carried by the group IV muscle afferents could be involved has often been raised but never measured in vivo in these conditions. In this experiment, we tested the response of the group IV muscle afferents from the lower limb to injections of KCl and lactic acid in non-exercising rats and at 1, 2, and 8 days after one running session (-13 degrees, 16 m/min). At days 1 and 2, the baseline discharge of the group IV afferents increased, but further activation by test agents was absent. After 8 days, the afferent response was equivalent to the control response. Pretreatment with betamethasone before exercise abolished the effects of downhill exercise. In non-exercising rats, arachidonic acid evoked group IV afferent discharge and suppressed their further response to another stimulus. These results demonstrate that exhaustive downhill running highly activates, for at least 2 days, the sensory feedback carried by group IV afferents through the local release of inflammatory mediators. Such an altered sensori-motor control, accompanying the ...Continue Reading

References

Jul 1, 1976·Cardiovascular Research·K Herbaczynska-CedroH Janczewska
Dec 28, 1976·Pflügers Archiv : European journal of physiology·C SteinhagenI Hosselmann
Dec 1, 1992·British Journal of Sports Medicine·M J Cleak, R G Eston
May 1, 1992·Medicine and Science in Sports and Exercise·P M ClarksonB Braun
Aug 1, 1990·Medicine and Science in Sports and Exercise·R B Armstrong
Aug 1, 1988·The American Journal of Anatomy·R W OgilvieC L Bottoms
Jul 1, 1987·Sports Medicine·T D Noakes
Oct 1, 1986·The Journal of Physiology·B R Bigland-RitchieO C Lippold
Sep 1, 1985·Journal of Applied Physiology·W C ByrnesR J Maughan
Jul 1, 1972·The Journal of Physiology·D I McCloskey, J H Mitchell
Aug 1, 1983·International Journal of Sports Medicine·J FridénB Ekblom
Jan 1, 1983·Clinical Science·D J NewhamR H Edwards
May 1, 1983·Journal of the Neurological Sciences·R S HikidaD L Costill
Jan 1, 1982·Circulation Research·M P KaufmanJ H Mitchell
Aug 1, 1995·Medicine and Science in Sports and Exercise·J M SaxtonA E Donnelly
Nov 1, 1993·The Journal of Physiology·J Duchateau, K Hainaut
May 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S H Mellon
Jan 1, 1997·European Journal of Applied Physiology and Occupational Physiology·M P MilesK R Vincent
Nov 11, 1998·European Journal of Applied Physiology and Occupational Physiology·J Avela, P V Komi
Apr 3, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S E TerblancheG A Brooks

❮ Previous
Next ❯

Citations

Apr 28, 2006·Experimental Brain Research·William GibsonThomas Graven-Nielsen
Aug 25, 2009·Pflügers Archiv : European journal of physiology·Stephane DelliauxYves Jammes
Feb 26, 2008·Journal of Strength and Conditioning Research·W Jackson DavisW Bart Davis
Apr 9, 2013·The Journal of Pain : Official Journal of the American Pain Society·Saad S Nagi, David A Mahns
Jun 15, 2011·The Journal of Pain : Official Journal of the American Pain Society·Simon AylesWilliam Gibson
Jan 7, 2010·Brain, Behavior, and Immunity·Martin D CarmichaelAbdul Ghaffar
Nov 17, 2007·Clinical Physiology and Functional Imaging·Sirous AhmadiGlen M Davis
Jan 16, 2014·Scandinavian Journal of Medicine & Science in Sports·R G TimminsA J Shield
Oct 25, 2016·Scandinavian Journal of Medicine & Science in Sports·M GiandoliniP Samozino
Jun 7, 2013·The American Journal of Sports Medicine·Gaël GuilhemSylvain Dorel
Jul 23, 2020·Medicine and Science in Sports and Exercise·Flavio DA SilvaSerge S Colson
Mar 26, 2019·Journal of Strength and Conditioning Research·Kyle J BrandenbergerJ Andrew Doyle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here