Eccles' perspective of the forebrain, its role in skilled movements, and the mind-brain problem

Progress in Neurobiology
Mario Wiesendanger

Abstract

Sir John Eccles' experimental life evolved from the "bottom" up: the synapse to the modular circuitry of the spinal cord, later the cerebellum and, less extensively, also the thalamus and hippocampus. He experimented quantitatively on basic properties of cell membranes, synapses, transmitters, cellular modules, reflexes, and plasticity. In parallel, he was also motivated to consider philosophical problems of mind-brain interactions. It was mostly during Eccles' "Swiss period" (1976-1997) that new experimental work advanced understanding of intentional motor actions and their preparation. For example, early brain imaging work suggested that the so-called "supplementary" motor area was rather a "supramotor" area, concerned with intentional preparation to move. Eccles also closely followed work on cortico-cerebellar integration and learning. His final contribution, in collaboration with the quantum physicist, Friedrich Beck, was a model of how specific neuronal modules interact with the mind. Being a declared dualist, Eccles encountered considerable resistance and skepticism among neuroscientists in accepting his experimentally untestable mind-brain theories. But one can only admire the remarkable continuity of effort in his searc...Continue Reading

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Citations

Oct 3, 2013·Journal of the History of the Neurosciences·Adrian R Morrison
May 3, 2006·Progress in Neurobiology·William D Willis
May 2, 2006·Progress in Neurobiology·Robert E Burke
May 2, 2006·Progress in Neurobiology·Jonathan R Wolpaw, Jonathan S Carp
Jul 26, 2011·Brain Research·Douglas G Stuart, Robert M Brownstone

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