PMID: 9533377Apr 9, 1998Paper

ECG changes during furosemide-induced hypokalemia in the rat

Journal of Electrocardiology
M AkitaS Sugano

Abstract

Electrolyte abnormalities have become an increasingly important cause of arrhythmias owing to the widespread use of high-potency diuretics. Hypokalemia is one of the common complications of diuretic use. Although some studies of hypokalemia induced by furosemide as well as of potassium-deficient diets in the rat have been reported, the electrocardiographic (ECG) changes during hypokalemia in the rat are poorly understood. This study was designed to examine such changes. For this purpose, hypokalemia was induced by furosemide administration, and the diagnostic criteria for ECG manifestations of hypokalemia were determined. During hypokalemia, conduction in most parts of the heart was suppressed to an extent depending on plasma potassium concentration. Prolongation of the QT interval was also observed, which agrees with findings in humans and dogs. Furthermore, prolonged durations of the P wave and QRS complex were observed during hypokalemia in the rat. The extent of alteration of the PR interval induced by hypokalemia was less significant than that of P wave and QRS complex durations. These results suggest that the excitabilities of the myocardium in the atria and ventricles may be affected by extracellular potassium level rath...Continue Reading

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Citations

Apr 10, 2013·European Journal of Pharmacology·Sanmoy KarmakarTuhinadri Sen
Jun 10, 2003·Critical Care : the Official Journal of the Critical Care Forum·Shinji FukuiKatsuji Shima
Oct 9, 2013·Journal of Electrocardiology·Chiharu KishimotoHiroyasu Kuwahara
Dec 12, 2007·Pacing and Clinical Electrophysiology : PACE·A Yucel ColkesenHaldun Muderrisoglu
Jun 30, 2010·Fundamental & Clinical Pharmacology·Oleg E Osadchii
Jun 12, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Chuan-Teng LiuMing-Yie Liu
Oct 25, 2003·Journal of Cardiovascular Pharmacology·András Farkas, Michael J Curtis
Dec 20, 2007·American Journal of Therapeutics·Samuel Ghasi, Gilbert Onuaguluchi
Aug 11, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Soren SnitkerUNKNOWN for CRIC Study Investigators
Jul 31, 2007·Experimental Animals·Takeshi TakagiKoichi Suzuki
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