Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production

Evidence-based Complementary and Alternative Medicine : ECAM
Yue-Hua WangGuan-Hua Du

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. Mitochondrial dysfunction and inflammatory responses are involved in the mechanism of cell damage in PD. 6-Hydroxydopamine (6-OHDA), a dopamine analog, specifically damages dopaminergic neurons. Echinacoside (ECH) is a phenylethanoid glycoside isolated from the stems of Cistanche salsa, showing a variety of neuroprotective effects in previous studies. The present study was to investigate its effect against 6-OHDA-induced neurotoxicity and possible mechanisms in PC12 cells. The results showed that 6-OHDA reduced cell viability, decreased oxidation-reduction activity, decreased mitochondrial membrane potential, and induced mitochondria-mediated apoptosis compared with untreated PC12 cells. However, echinacoside treatment significantly attenuated these changes induced by 6-OHDA. In addition, echinacoside also could significantly alleviate the inflammatory responses induced by 6-OHDA. Further research showed that echinacoside could reduce 6-OHDA-induced ROS production in PC12 cells. These results suggest that the underlying mechanism of echinacoside against 6-OHDA-induced neurotoxicity may...Continue Reading

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Citations

Aug 2, 2016·Oxidative Medicine and Cellular Longevity·Sergio Di MeoVictor Manuel Victor
Oct 6, 2016·Frontiers in Pharmacology·Caimei GuLinfang Huang
Jan 19, 2018·Aging and Disease·Ningqun WangXianglan Jin
Feb 16, 2019·Phytotherapy Research : PTR·Hongnan ZhengJianbo Wang
Aug 18, 2020·Journal of Lasers in Medical Sciences·Fatemeh Sadat Tabatabaei MirakabadShahrokh Khoshsirat
Jul 27, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Dongfang WangLi Gu
May 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingjing LiuXueqin Ma
Feb 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chien-Liang ChaoHang-Ching Lin
Apr 6, 2019·Advances in Pharmacological Sciences·Adaze Bijou EnogieruOkobi Eko Ekpo
Jun 12, 2021·Neuropsychiatric Disease and Treatment·Zhen-Nian ZhangYang Zhao

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Methods Mentioned

BETA
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