Echinochrome Exhibits Antitumor Activity against Ehrlich Ascites Carcinoma in Swiss Albino Mice.

Nutrition and Cancer
Ayman Saber Mohamed

Abstract

Background: Echinochrome (Ech) is a common pigment present in sea urchins, which has antioxidant, antimicrobial, antialgal, hypolipidemic and hypoglycemic activities.Purpose: The present investigation assessed the anticancer and antioxidant activities of Ech against the Ehrlich ascites carcinoma tumor model in mice.Methods: Forty female mice were divided into four groups (n = 10). All groups except the group I received EAC cells (5 × 106 cells/mouse i.p.). Group I, served as saline control (5 ml/kg 0.9% NaCl w/v p.o); group II served as EAC; groups III and IV received Ech (1 mg/kg body weight i.p.), and reference drug (5-Fu, 20 mg/kg body weight i.p.) respectively. Tumor markers, hematological parameters, liver functions, kidney functions and oxidative stress markers were analyzed in the present study.Results: A significant decrease (p < 0.05) were detected in the tumor volume, tumor cell counts, tumor cells viability, WBC count, MDA, urea, uric acid, AST, ALT, and ALP levels in Ech-treated mice. Furthermore, Ech-treated mice showed significant increases in RBCs count, Hb, Pt, GSH, CAT, and GST levels.Conclusion: The study results revealed that echinochrome suppresses tumor growth, decreases lipid peroxidation and improves the ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Sep 1, 1979·Biochemical Pharmacology·O Greengard
Dec 1, 1991·The American Journal of Clinical Nutrition·A SevanianP Hochstein
Dec 1, 1971·Archives of Disease in Childhood·A Belfield, D M Goldberg
Jan 1, 1969·Comparative Biochemistry and Physiology·H A AndersonR H Thomson
Jan 1, 1984·Methods in Enzymology·H Aebi
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Mar 1, 1960·Journal of Clinical Pathology·J K FAWCETT, J E SCOTT
Aug 4, 2007·Phytotherapy Research : PTR·Santoshkumar H DongreAshok Godavarthi
Jun 11, 2009·Bulletin of Experimental Biology and Medicine·N P MischenkoA S Ratushnyak
Aug 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·Jalila Ben Salah-AbbèsRidha Oueslati
Jan 15, 2010·Plant Foods for Human Nutrition·Syed Sultan BeeviBandi Boje Gowda
Aug 21, 2010·Basic & Clinical Pharmacology & Toxicology·Satoshi NumazawaTakemi Yoshida
Nov 26, 2010·Pharmaceutical Biology·Pallab Kanti HaldarUpal Kanti Mazumder
Jun 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Roger YazbeckGordon S Howarth
Mar 8, 2016·Life Sciences·Ayman Saber MohamedMohamed Assem Said Marie

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Citations

Feb 1, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ayman Saber MohamedSohair Ramadan Fahmy
Aug 27, 2021·Marine Drugs·Hyoung Kyu KimJin Han

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