Echinococcus multilocularis: the impact of ionizing radiation on metacestodes

Experimental Parasitology
Sebastian PohleStephan Gripp

Abstract

Alveolar echinococcosis is caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis. Current chemotherapeutical options for the treatment of echinococcosis are not satisfactory, and novel drugs and/or other potential means of therapy are needed. E. multilocularis metacestodes are characterized by almost potentially unlimited growth, and also display other features of cancerous tumours. In this study, we exposed metacestodes that were generated in vitro to 50-100 Gy ionizing irradiation, and subsequently investigated the short-term (10-12 days post-treatment) and long-term (14 weeks post-treatment) effects. We found, that in the short-term, no release of alkaline phosphatase (EmAP) activity as a measure for potentially induced damage and loss of viability could be detected, and that the protein expression pattern and protease activities in vesicle fluids and medium supernatants did not alter dramatically following irradiation. However, irradiation was associated with distinct morphological and ultrastructural alterations in the tissue of metacestodes, affecting most notably cell-cell contacts, mitochondrial shape, glycogen-storage cells and lipid droplet formation. These could be detected already at 10 day...Continue Reading

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Citations

Jan 29, 2014·Experimental Parasitology·M F DomínguezE Castillo
Apr 23, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S UlgerN Karaoğlanoğlu
Aug 25, 2015·Veterinary Parasitology·U Koziol, K Brehm
May 20, 2015·Parasitology Research·Yosra Hussein Alam-Eldin, Abeer Fathy Badawy
Jan 15, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Andreas Neumayr
Dec 23, 2014·Parasite : Journal De La Société Française De Parasitologie·Francesca TamarozziStéphane Koch
Mar 25, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stephan GrippSebastian Pohle
Jul 9, 2020·Foods·Muhammad Tanveer Munir, Michel Federighi
Sep 25, 2017·BMC Infectious Diseases·Rui MaoWenbao Zhang

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